FAQ

CYP2E1 wt Allele

Known as: P450C2E, Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 wt Allele, CYP2E 
Human CYP2E1 wild-type allele is located within 10q24.3-qter and is approximately 12 kb in length. This allele, which encodes cytochrome P4502E1… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2018
051019872018

Related topics

Related topics

16 relations
Arachidonic Acid Metabolism PathwayCarcinogen MetabolismCarcinoma of lungCytochrome P-450 CYP2E1
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Broader (1)

CYP2E1 gene

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CYP2E1 wt Allele
Carcinoma of lung
Oxidation-Reduction
Homo sapiens
Metabolic Detoxication, Drug
drug metabolism

Papers overview

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2004
2004
Phase I and II enzyme characterization of two sources of HepG2 cell lines.
1: The metabolism by HepG2 cell from two sources (M1, M2) of 12 substrates is reported: ethoxyresorufin, ethoxycoumarin… (More)
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Highly Cited
2003
Highly Cited
2003
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Cultured human hepatocytes are a valuable in vitro system for evaluating new molecular entities as inducers of cytochrome P450… (More)
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2002
2002
Thalidomide metabolism by the CYP2C subfamily.
PURPOSE This research investigated the biotransformation of thalidomide by cytochrome P-450 (CYP). EXPERIMENTAL DESIGN We used… (More)
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2000
2000
Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract.
We studied the long-term effects of streptozotocin-induced diabetes on tissue-specific cytochrome P450 (CYP) and glutathione… (More)
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2000
2000
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the… (More)
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1997
1997
Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate…
Molecular modelling of substrates of cytochrome P4502E1 (CYP2E1) within the putative active site region of CYP2E1 constructed… (More)
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1995
1995
Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes.
In primary cultures of human hepatocytes prepared from three separate livers, ethanol increased both CYP3A and CYP2E1, as… (More)
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1994
1994
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.
Tropisetron and ondansetron, which are potent and selective 5-hydroxytryptamine (5-HT3) receptor antagonists, were both… (More)
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1990
1990
PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene.
Source/Description: A 1.5 kb Apal-Apal fragment, containing 5' upstream sequences of the human CYP2E gene (1). Polymorphism: Pstl… (More)
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1988
1988
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.
The human P450IIE1 gene, coding for an ethanol-inducible nitrosamine-metabolizing P-450, was isolated from a lambda EMBL3 genomic… (More)
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