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CYP2E1 wt Allele

Known as: P450C2E, Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 wt Allele, CYP2E 
Human CYP2E1 wild-type allele is located within 10q24.3-qter and is approximately 12 kb in length. This allele, which encodes cytochrome P4502E1… Expand
National Institutes of Health

Related topics

Related topics

17 relations
Arachidonic Acid Metabolism PathwayCarcinogen MetabolismCarcinoma of lungCytochrome P-450 CYP2E1
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Broader (1)

CYP2E1 gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling.
In many liver disorders, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally… Expand
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2012
2012
RNA Sequencing Reveals Dynamic Changes of mRNA Abundance of Cytochromes P450 and Their Alternative Transcripts during Mouse Liver Development
Cytochromes P450 (P450s) are a superfamily of enzymes that have critical functions in liver to catalyze the biotransformation of… Expand
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Review
2008
Review
2008
Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure.
Heart failure is a very serious cardiovascular disease that affects more than five million people in North America. The role of… Expand
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Highly Cited
2004
Highly Cited
2004
Phase I and II enzyme characterization of two sources of HepG2 cell lines
1. The metabolism by HepG2 cell from two sources (M1, M2) of 12 substrates is reported: ethoxyresorufin, ethoxycoumarin… Expand
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Highly Cited
2003
Highly Cited
2003
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Cultured human hepatocytes are a valuable in vitro system for evaluating new molecular entities as inducers of cytochrome P450… Expand
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Highly Cited
2002
Highly Cited
2002
Thalidomide metabolism by the CYP2C subfamily.
PURPOSE This research investigated the biotransformation of thalidomide by cytochrome P-450 (CYP). EXPERIMENTAL DESIGN We used… Expand
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Highly Cited
2000
Highly Cited
2000
Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract.
We studied the long-term effects of streptozotocin-induced diabetes on tissue-specific cytochrome P450 (CYP) and glutathione… Expand
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Highly Cited
2000
Highly Cited
2000
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the… Expand
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2000
2000
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
Little information is available regarding the vasoactive effects of epoxyeicosatrienoic acids (EETs) in the lung. We demonstrate… Expand
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Highly Cited
1988
Highly Cited
1988
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.
The human P450IIE1 gene, coding for an ethanol-inducible nitrosamine-metabolizing P-450, was isolated from a lambda EMBL3 genomic… Expand
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