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CYP2E1 gene

Known as: CYTOCHROME P450, SUBFAMILY IIE, Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Gene, P450C2E 
This gene is involved in the metabolism of both endogenous and exogenous substrates.
National Institutes of Health

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CYP2E1 wt Allele
Carcinogen MetabolismCarcinoma of lungCytochrome P-450 CYP2E1Cytochrome P450 2E1, human
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Papers overview

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2019
2019
Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis
Circulating extracellular vesicles (EVs) are a novel and emerging biomarker for nonalcoholic steatohepatitis (NASH). It has been… Expand
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2018
2018
No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population.
Cytochrome P450 2E1 (CYP2E1) gene is one of the candidate genes for alcohol dependence (AD). Four single nucleotide polymorphisms… Expand
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2018
2018
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin
Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced… Expand
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2017
2017
miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression.
Acetaminophen toxicity is a leading cause of acute liver failure (ALF). We found that miRNA-122 (miR-122) is down-regulated in… Expand
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2017
2017
Pien Tze Huang Gan Bao attenuates carbon tetrachloride-induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress
Pien Tze Huang Gan Bao (PZH-GB), a traditional Chinese medicine, has been used for thousands of years as a protective remedy… Expand
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2017
2017
Does Genetic Loss of Immunoglobulin A Have No Impact on Alcoholic Liver Disease?
CHRONIC ALCOHOL ABUSE leads to liver injury in the manifestation of hepatic steatosis, hepatitis, fibrosis, cirrhosis, and cancer… Expand
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2011
2011
Transgenic plants of Petunia hybrida harboring the CYP2E1 gene efficiently remove benzene and toluene pollutants and improve resistance to formaldehyde
The CYP2E1 protein belongs to the P450 enzymes family and plays an important role in the metabolism of small molecular and… Expand
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2004
2004
Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1.
Styrene is widely used in the production of various plastics, synthetic rubber and resins. The aim of this study was to evaluate… Expand
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1995
1995
CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese.
The genotypes of the CYP2E1 and ALDH2 loci of alcoholic (alcohol dependence) and nonalcoholic (healthy) Japanese were… Expand
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1995
1995
Cytochrome P4502E1 genetic polymorphisms and risk of nasopharyngeal carcinoma: results from a case-control study conducted in Taiwan.
CYP2E1 is responsible for the metabolic activation of nitrosamines believed to be involved in the pathogenesis of various tumors… Expand
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