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CYP2D6*5 Allele

Known as: CYP2D6 Deleted, CYP2D6*5, CYP2D6D 
Human CYP2D6*5 allele is a variant form of the CYP2D6 wild-type allele. The CYP2D6*5 allele is a result of deletion of the entire CYP2D6 gene. Thus… 
National Institutes of Health

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22q13.1Inactive - Biochemical Activity LevelIron ChelationMetabolic Detoxication, Drug

Papers overview

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2010
2010
Selections from a literature search on the effects , mechanism of action , and metabolism of mCPP , the principal metabolite of Trazodone , with references
Trazodone, a triazolepyridine derivate, is both chemically and pharmacologically distinct from other serotonin reuptake… 
2010
2010
Influence of CYP2D6 Deletion, Multiplication, –1584C→G, 31G→A and 2988G→A Gene Polymorphisms on Dextromethorphan Metabolism among Mexican Tepehuanos and Mestizos
The aim of this study was to explain the variability of CYP2D6 activity by the identification of CYP2D6 deletion and… 
2005
2005
Novel structure of the CYP2D6 gene that confuses genotyping for the CYP2D6*5 allele.
We encountered DNA samples which showed a positive product using a long PCR-based method for the detection of CYP2D6*5… 
2004
2004
A long PCR assay to distinguish CYP2D6*5 and a novel CYP2D6 mutant allele associated with an 11-kb EcoRI haplotype.
2003
2003
Standard CYP2D6 genotyping procedures fail for the CYP2D6*5 and duplication alleles when hair roots are used as a source of DNA.
1999
1999
GENETIC BIAS COULD NOT BE IGNORED IN CLINICAL TRIALS
AIM: To evaluate if there is a genetic bias in clinical trials. METHODS: Genotyping of the CYP2D6A, CYP2D6B, CYP2D6D, CYP2D6E and… 
1999
1999
The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population
We investigated the effect of cytochrome P450 (CYP2D6) genotypes on plasma levels of haloperidol (HAL) and reduced haloperidol… 
1997
1997
The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients.
The relationship between therapeutic response to racemic mianserin and steady-state plasma concentrations of S(+)- and R… 
1994
1994
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
OBJECTIVE To determine whether particular genotypes for the cytochrome P450 enzyme CYP2D6, a polymorphic enzyme, are associated… 
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