CYP1A1 gene

Known as: CYTOCHROME P1-450, INDUCIBLE BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, AHH, P1-450 
This gene plays a role in the oxidation of procarcinogens. This process activates these compounds to carcinogens.

Topic mentions per year

Topic mentions per year

1972-2018
020406019722018

Papers overview

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2002
2002
OBJECTIVE Gene-environment interactions have been the focus of a number of recent studies of the occurrence of human cancers, and… (More)
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Highly Cited
2000
Highly Cited
2000
The genotypic basis of interindividual variation in levels of induced CYP1A1 activity has been investigated by screening both the… (More)
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1998
1998
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) induces gene transcription, a process that… (More)
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Highly Cited
1994
Highly Cited
1994
At least two different polymorphisms in the human CYP1A1 gene have been associated with an increased risk for tobacco-related… (More)
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Highly Cited
1994
Highly Cited
1994
Genetic susceptibility factors may play a role in determining adverse effects of exposure to environmental toxins. As a… (More)
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Highly Cited
1993
Highly Cited
1993
An association of lung cancer susceptibility with an MspI restriction site polymorphism of the CYP1A1 gene was reported in our… (More)
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Highly Cited
1993
Highly Cited
1993
A comparative study of human CYP1A1 genotypes and enzymatic activity was performed in a racially diverse population in order to… (More)
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1993
1993
A new Msp1 RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A… (More)
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Highly Cited
1990
Highly Cited
1990
The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary… (More)
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Highly Cited
1988
Highly Cited
1988
Anticarcinogenic enzyme inducers are of two types: (a) bifunctional inducers [2,3,7,8-tetrachlorodibenzo-p-dioxin, polycyclic… (More)
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