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CYP1A1 gene

Known as: CYTOCHROME P1-450, INDUCIBLE BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, AHH, P1-450 
This gene plays a role in the oxidation of procarcinogens. This process activates these compounds to carcinogens.
National Institutes of Health

Related topics

Related topics

15 relations
Aryl Hydrocarbon HydroxylasesCYP1A1 protein, humanCYP1B1 geneCYP27B1 gene

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CYP1A1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
2000
2000
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
Cytochrome P450 (CYP) CYP1A1 activates tobacco-related carcinogens. A point mutation at codon 462 in exon 7 of CYP1A1 results in… 
Highly Cited
1995
Highly Cited
1995
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Msp I polymorphism and exon 7 Ile-Val polymorphism of CYP1A1, and Rsa I polymorphism of CYP2E1 were studied in lung cancer… 
Highly Cited
1994
Highly Cited
1994
Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout.
In animals, exposure to polyaromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (3-MC) is known to induce the expression of… 
Highly Cited
1984
Highly Cited
1984
Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols.
Binding of the polycyclic aromatic hydrocarbon (PAH) carcinogens [3H]benzo(a)pyrene (BP) and [3H]dibenz(a,h)anthracene [DB(a,h)A… 
Highly Cited
1980
Highly Cited
1980
Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin.
Highly Cited
1978
Highly Cited
1978
The genetic basis of susceptibility to leukemia induction in mice by 3- methylcholanthrene applied percutaneously
Susceptibility to leukemia induction in mice by skin painting with 3- methylcholanthrene (MCA) is strain-specific, occurring only… 
Highly Cited
1978
Highly Cited
1978
Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer
To test whether the distribution of AHH inducibility is shifted toward the high end of the range in patients who had lung and… 
Highly Cited
1975
Highly Cited
1975
Alterations in microsomal metabolism of benzo[a]pyrene in mice fed butylated hydroxyanisole.
The metabolism of benzo[a]pyrene (BP) by liver microsomes in female A/HeJ mice fed a control diet or a diet containing butylated… 
Highly Cited
1974
Highly Cited
1974
Experimental Lung Cancer
The development of cancer depends upon the integrated response of the host to the carcinogen and to the initial transformation… 
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