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CYP1A1 protein, human

Known as: Cytochrome P450 Form 6, Flavoprotein-Linked Monooxygenase, CYP1A1 
Cytochrome P450 1A1 (512 aa, ~58 kDa) is encoded by the human CYP1A1 gene. This protein is involved in the metabolism of fatty acids and xenobiotics.
National Institutes of Health

Related topics

Related topics

20 relations

Broader (2)

Aryl Hydrocarbon HydroxylasesCytochrome P-450 CYP1A1
CYP1A1 geneCYP1A1 wt AlleleCarcinogen MetabolismCarcinoma of lung

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.
Highly Cited
2007
Highly Cited
2007
Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women
Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the… 
2007
2007
Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women.
The authors investigated whether polymorphisms in two maternal metabolic genes, cytochrome P-450 1A1 (CYP1A1) MspI and epoxide… 
2006
2006
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells
Purpose: The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) exhibits… 
2004
2004
Suppression by p38 MAP Kinase Inhibitors (Pyridinyl Imidazole Compounds) of Ah Receptor Target Gene Activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Possible Mechanism*
Cytochrome P-450 1A1 (CYP1A1) is known to be induced by aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD… 
2003
2003
Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines.
Review
2003
Review
2003
The effect of cigarette smoke exposure and ascorbic acid intake on gene expression of antioxidant enzymes and other related enzymes in the livers and lungs of Shionogi rats with osteogenic disorders.
Cigarette smoking causes many chronic diseases but is a preventable risk factor in developing countries. However, it may be… 
Highly Cited
2000
Highly Cited
2000
Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity.
Steroid hydroxylation specificities were determined for the wild-type and the two allelic variants of the polymorphic human… 
1999
1999
The Steroid Hormone Dehydroepiandrosterone InhibitsCYP1A1 Expression in Vitro By a Post-transcriptional Mechanism*
The adrenal steroid hormone dehydroepiandrosterone (DHEA) is a potent inhibitor of mammary carcinogenesis induced by polycyclic… 
1995
1995
Radical differences in CYP1A1 genotype and function.
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