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CYLD gene

Known as: USPL2, KIAA0849, CYLD 
This gene is involved in protein deubiquitination.
National Institutes of Health

Related topics

Related topics

9 relations
Ancell-Spiegler cylindromasCYLD protein, humanDeubiquitinationEccrine dermal cylindroma
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CYLD wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. The understanding of its gene expression… Expand
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Highly Cited
2008
Highly Cited
2008
CYLD mutations in familial skin appendage tumours
Background: Germ-line mutations in CYLD are found in patients with familial skin appendage tumours. The protein product functions… Expand
2007
2007
Quantitative comparison of IMAC and TiO2 surfaces used in the study of regulated, dynamic protein phosphorylation
Protein phosphorylation regulates many aspects of cellular function, including cell proliferation, migration, and signal… Expand
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Highly Cited
2006
Highly Cited
2006
Regulation of T cell development by the deubiquitinating enzyme CYLD
T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the… Expand
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2006
2006
Diverse phenotype of Brooke–Spiegler syndrome associated with a nonsense mutation in the CYLD tumor suppressor gene
Abstract:  Brooke–Spiegler syndrome (BSS) is an autosomal dominant disease characterized by cylindromas, trichoepitheliomas and… Expand
Highly Cited
2004
Highly Cited
2004
CYLD mutation causes multiple familial trichoepithelioma in three Chinese families
Multiple familial trichoepithelioma (MFT) and familial cylindromatosis are two clinically distinct cancer syndromes. MFT patients… Expand
Highly Cited
2002
Highly Cited
2002
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
The ubiquitin (Ub)-proteasome system includes a large family of deubiquitinating enzymes (DUBs). Many members are assigned to… Expand
Highly Cited
2002
Highly Cited
2002
Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages.
Familial cylindromatosis (turban tumor syndrome; Brooke-Spiegler syndrome) (OMIM numbers 123850, 132700, 313100, and 605041) is a… Expand
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Highly Cited
2002
Highly Cited
2002
Spiradenocylindroma of the Kidney: Clinical and Genetic Findings Suggesting a Role of Somatic Mutation of the CYLD1 Gene in the Oncogenesis of an Unusual Renal Neoplasm
We describe the morphology and comparative genomic hybridization findings in a tumor for which we propose the term… Expand
Highly Cited
2000
Highly Cited
2000
Identification of the familial cylindromatosis tumour-suppressor gene
Familial cylindromatosis is an autosomal dominant genetic predisposition to multiple tumours of the skin appendages. The… Expand
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