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CX3CL1 protein, human

Known as: SCYD1 protein, human, Small-Inducible Cytokine D1, Fractalkine 
Fractalkine (397 aa, ~42 kDa) is encoded by the human CX3CL1 gene. This protein is involved in chemotaxis of T-cells and monocytes.
National Institutes of Health

Related topics

Related topics

15 relations
Biologic DevelopmentCX3CL1 geneCell AdhesionCentral Nervous System

Broader (1)

Fractalkine

Papers overview

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Highly Cited
2015
Highly Cited
2015
Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina
Fractalkine (CX3CL1 or FKN) is a membrane-bound chemokine expressed on neuronal membranes and is proteolytically cleaved to shed… 
2015
2015
Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients
IntroductionFractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine… 
Highly Cited
2006
Highly Cited
2006
Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn
Highly Cited
2006
Highly Cited
2006
The Chemokine CX3CL1 Reduces Migration and Increases Adhesion of Neurons with Mechanisms Dependent on the β1 Integrin Subunit1
Fractalkine/CX3CL1 and its specific receptor CX3CR1 are constitutively expressed in several regions of the CNS and are reported… 
Highly Cited
2004
Highly Cited
2004
Fractalkine reduces N‐methyl‐d‐aspartate‐induced calcium flux and apoptosis in human neurons through extracellular signal‐regulated kinase activation
Our purpose was to investigate in human neurons the neuroprotective pathways induced by Fractalkine (FKN) against glutamate… 
Highly Cited
2001
Highly Cited
2001
Fractalkine induces chemotaxis and actin polymerization in human dendritic cells
Abstract.Objective and design: Dendritic cells (DCs) are considered as the principle initiators of immune responses by virtue of… 
2001
2001
Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes.
Fractalkine is a CX3C chemonkine that appears to be a neuron-to-microglia signal molecule in the central nervous system. We… 
Highly Cited
2000
Highly Cited
2000
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.
Highly Cited
2000
Highly Cited
2000
The role of fractalkine in the recruitment of monocytes to the endothelium.
Highly Cited
2000
Highly Cited
2000
The Crystal Structure of the Chemokine Domain of Fractalkine Shows a Novel Quaternary Arrangement*
Fractalkine, or neurotactin, is a chemokine that is present in endothelial cells from several tissues, including brain, liver… 
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