Fractalkine

Known as: Chemokine (C-X3-C Motif) Ligand 1, Chemokine CX3CL1 [Chemical/Ingredient], Neurotactin 
A CX3C chemokine that is a transmembrane protein found on the surface of cells. The soluble form of chemokine CX3CL1 can be released from cell… (More)
National Institutes of Health

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CX3CL1 geneIn BloodNrt protein, DrosophilaProcess of secretion
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CX3CL1 protein, human

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chemokine

Papers overview

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Highly Cited
2004
Highly Cited
2004
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The present experiments examined the role of spinal proinflammatory cytokines [interleukin-1beta (IL-1)] and chemokines… (More)
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Highly Cited
2003
Highly Cited
2003
Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes
CD16+ monocytes represent 5-10% of peripheral blood monocytes in normal individuals and are dramatically expanded in several… (More)
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Highly Cited
2003
Highly Cited
2003
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.
The hallmark of early atherosclerosis is the accumulation of lipid-laden macrophages in the subendothelial space. Circulating… (More)
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Highly Cited
2002
Highly Cited
2002
CX(3)C chemokine fractalkine in pulmonary arterial hypertension.
Perivascular infiltrates composed of macrophages and lymphocytes have been described in lung biopsies of patients displaying… (More)
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Highly Cited
2000
Highly Cited
2000
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.
The seven-transmembrane receptor CX(3)CR1 is a specific receptor for the novel CX(3)C chemokine fractalkine (FKN) (neurotactin… (More)
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Highly Cited
2000
Highly Cited
2000
Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage.
Fractalkine is a recently identified chemokine that exhibits cell adhesion and chemoattractive properties. It represents a unique… (More)
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Highly Cited
1998
Highly Cited
1998
Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.
A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which consists principally of secreted… (More)
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Highly Cited
1998
Highly Cited
1998
Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow
Leukocyte migration into sites of inflammation involves multiple molecular interactions between leukocytes and vascular… (More)
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Highly Cited
1998
Highly Cited
1998
Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?
Localization of the mRNAs for fractalkine, a CX3C chemokine, and for its receptor CX3CR1 was investigated in the rat brain. In… (More)
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Highly Cited
1997
Highly Cited
1997
Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion
Leukocyte trafficking at the endothelium requires both cellular adhesion molecules and chemotactic factors. Fractalkine, a novel… (More)
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