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Severe sepsis and septic shock.
Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment ofExpand
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Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cellsExpand
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Inflammation and coagulation
In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation leads toExpand
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Bidirectional Relation Between Inflammation and Coagulation
Inflammation and coagulation play pivotal roles in the pathogenesis of vascular disease. Increasing evidence points to extensive cross-talk between these two systems, whereby inflammation leads notExpand
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Sepsis: a roadmap for future research.
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on earlyExpand
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Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.
Short-term preexposure of mononuclear cells to epinephrine inhibits LPS-induced production of TNF, whereas preexposure for 24 h results in increased TNF production. To assess the effects ofExpand
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Host-pathogen interactions in sepsis.
Sepsis is a major health problem. The concept that sepsis mortality is the result of an uncontrolled hyperinflammatory host response has recently been challenged. It is now widely thought that theExpand
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Activation of coagulation after administration of tumor necrosis factor to normal subjects.
Tumor necrosis factor has been implicated in the activation of blood coagulation in septicemia, a condition commonly associated with intravascular coagulation and disturbances of hemostasis. ToExpand
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The cholinergic nervous system can inhibit the release of proinflammatory cytokines such as TNF-α from LPS-stimulated macrophages. Acetylcholine, the principal neurotransmitter of the vagus nerve, isExpand
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Host–Pathogen Interaction in Invasive Salmonellosis
Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but whose clinicalExpand
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