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- Publications
- Influence
Severe sepsis and septic shock.
- D. Angus, T. van der Poll
- Medicine
- The New England journal of medicine
- 28 August 2013
Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the basis, diagnosis, and current treatment of… Expand
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
- J. Leemans, G. Stokman, +7 authors S. Florquin
- Medicine
- The Journal of clinical investigation
- 3 October 2005
TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cells… Expand
Inflammation and coagulation
- M. Levi, T. van der Poll
- Medicine
- Critical care medicine
- 1 February 2010
In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation leads to… Expand
Bidirectional Relation Between Inflammation and Coagulation
- M. Levi, T. van der Poll, H. Büller
- Medicine
- Circulation
- 8 June 2004
Inflammation and coagulation play pivotal roles in the pathogenesis of vascular disease. Increasing evidence points to extensive cross-talk between these two systems, whereby inflammation leads not… Expand
Sepsis: a roadmap for future research.
- J. Cohen, J. Vincent, +10 authors E. Pelfrene
- Medicine
- The Lancet. Infectious diseases
- 1 May 2015
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early… Expand
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.
- T. van der Poll, S. Coyle, K. Barbosa, C. C. Braxton, S. Lowry
- Medicine
- The Journal of clinical investigation
- 1 February 1996
Short-term preexposure of mononuclear cells to epinephrine inhibits LPS-induced production of TNF, whereas preexposure for 24 h results in increased TNF production. To assess the effects of… Expand
Host-pathogen interactions in sepsis.
- T. van der Poll, S. Opal
- Biology, Medicine
- The Lancet. Infectious diseases
- 2008
Sepsis is a major health problem. The concept that sepsis mortality is the result of an uncontrolled hyperinflammatory host response has recently been challenged. It is now widely thought that the… Expand
Activation of coagulation after administration of tumor necrosis factor to normal subjects.
- T. van der Poll, H. Büller, +7 authors J. T. ten Cate
- Medicine
- The New England journal of medicine
- 7 June 1990
Tumor necrosis factor has been implicated in the activation of blood coagulation in septicemia, a condition commonly associated with intravascular coagulation and disturbances of hemostasis. To… Expand
LOCAL STIMULATION OF α7 CHOLINERGIC RECEPTORS INHIBITS LPS-INDUCED TNF-α RELEASE IN THE MOUSE LUNG
- I. A. Giebelen, D. V. van Westerloo, G. Larosa, A. D. de Vos, T. van der Poll
- Chemistry, Medicine
- Shock
- 1 July 2007
The cholinergic nervous system can inhibit the release of proinflammatory cytokines such as TNF-α from LPS-stimulated macrophages. Acetylcholine, the principal neurotransmitter of the vagus nerve, is… Expand
Host–Pathogen Interaction in Invasive Salmonellosis
- H. D. de Jong, C. Parry, T. van der Poll, W. J. Wiersinga
- Biology, Medicine
- PLoS pathogens
- 1 October 2012
Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but whose clinical… Expand