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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Severe sepsis and septic shock.
TLDR
A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
TLDR
Analysis of chimeric mice suggested that TLR2 expressed on renal parenchyma plays a crucial role in the induction of inflammation and injury, implying thatTLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury.
Inflammation and coagulation
TLDR
It is shown that activation of the coagulation system and ensuing thrombin generation is dependent on expression of tissue factor and the simultaneous down-regulation of endothelial-bound anticoagulant mechanisms and endogenous fibrinolysis, and activated coagulations may affect specific cellular receptors on inflammatory cells and endothelial cells and thereby modulate the inflammatory response.
Bidirectional Relation Between Inflammation and Coagulation
TLDR
Coagulation factors or anticoagulant proteins may activate specific cell receptors on mononuclear cells or endothelial cells, which may affect, for example, cytokine production or inflammatory cell apoptosis.
Sepsis: a roadmap for future research.
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.
TLDR
In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may help in understanding heterogeneity of treatment effects.
Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
TLDR
In an emergency care setting, both lymphocytopenia and NLCR are better predictors of bacteremia than routine parameters like CRP level, WBC count and neutrophil count.
Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization
TLDR
It is demonstrated for the first time that the Ixodes scapularis salivary protein Salp15 inhibits adaptive immune responses by suppressing human dendritic cell (DC) functions, and triggers a novel Raf-1/MEK-dependent signaling pathway acting at both cytokine transcriptional and post-transcriptional level to modulate Toll-like receptor–induced DC activation.
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