CX 5461

Known as: CX5461, RNA Pol I Inhibitor CX5461, Pol I Inhibitor CX5461 
An orally bioavailable inhibitor of RNA polymerase I (Pol I), with potential antineoplastic activity. Upon oral administration, CX-5461 selectively… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
051020112017

Papers overview

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2017
2017
G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes… (More)
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2017
2017
Dysregulation of MYC is frequently implicated in both early and late myeloma progression events, yet its therapeutic targeting… (More)
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2016
2016
RNA polymerase I (Pol I)-mediated transcription of the ribosomal RNA genes (rDNA) is confined to the nucleolus and is a rate… (More)
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2016
2016
Osteosarcoma (OS) is the most common primary bone tumor, but molecular mechanisms of the disease have not been well understood… (More)
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2015
2015
Ribosome biogenesis is a fundamental cellular process and is elevated in cancer cells. As one of the most energy consuming… (More)
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2015
2015
Enhanced rRNA synthesis is a downstream effect of many of the signaling pathways that are aberrantly activated in cancer, such as… (More)
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2014
2014
  • Cancer discovery
  • 2014
In a preclinical study, the investigational drug CX-5461, which blocks the protein RNA polymerase I, extended survival in mouse… (More)
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Highly Cited
2012
Highly Cited
2012
Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common feature of human cancer, but whether it is… (More)
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2012
2012
Accelerated proliferation of solid tumor and hematologic cancer cells is linked to accelerated transcription of rDNA by the RNA… (More)
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Highly Cited
2011
Highly Cited
2011
Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA polymerase (Pol) I, the… (More)
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