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CV-11974

Known as: CV 11974, CV11974 
National Institutes of Health

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1 relation

Broader (1)

candesartan

Papers overview

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Highly Cited
2006
Highly Cited
2006
Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system.
Highly Cited
2005
Highly Cited
2005
Activation of AP-1 through reactive oxygen species by angiotensin II in rat cardiomyocytes.
Highly Cited
2001
Highly Cited
2001
Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells
Recently, it was shown that Rho-kinase plays an important role in blood pressure regulation. However, it is not known whether Rho… 
Highly Cited
2000
Highly Cited
2000
Oxidized LDL Upregulates Angiotensin II Type 1 Receptor Expression in Cultured Human Coronary Artery Endothelial Cells: The Potential Role of Transcription Factor NF-&kgr;B
BackgroundWe demonstrated earlier that angiotensin II (Ang II), by AT1 receptor activation, upregulates oxidized LDL (ox-LDL… 
Highly Cited
2000
Highly Cited
2000
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
Activation of the sympathetic nervous system and renin-angiotensin system has been suggested to contribute to the hypertension… 
Highly Cited
1999
Highly Cited
1999
Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes.
This study was designed to determine whether mechanical stretch activates the Janus kinase (JAK)/signal transducers and… 
Highly Cited
1999
Highly Cited
1999
Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells.
Recent studies suggest that atherosclerosis is a kind of inflammatory process and that cytokine plays important roles in this… 
Highly Cited
1998
Highly Cited
1998
Losartan inhibits thromboxane A2-induced platelet aggregation and vascular constriction in spontaneously hypertensive rats.
Our recent studies have shown that the nonpeptide angiotensin II (Ang II) antagonist losartan interacts with thromboxane A2… 
Highly Cited
1995
Highly Cited
1995
Angiotensin II receptor antagonist CV‐11974 and cerebral blood flow autoregulation
Objective: To investigate whether the angiotensin II (Ang II) subtype 1 receptor (AT1) antagonist CV-11974 had a similar effect… 
Highly Cited
1993
Highly Cited
1993
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974…
The angiotensin II (AII) antagonistic action of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-benzi mid azole-7… 
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