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CTTN protein, human
Known as:
Amplaxin
, Oncogene EMS1
, EMS1
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Src substrate cortactin (550 aa, ~62 kDa) is encoded by the human CTTN gene. This protein is involved in the regulation of both the interactions…
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National Institutes of Health
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Related topics
Related topics
14 relations
Actin-Binding Protein
Agrin Pathway
CTTN gene
CTTN wt Allele
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Broader (1)
Cortactin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance
Yi-Kai Chen
,
Y. Hsueh
Journal of Neuroscience
2012
Corpus ID: 12508227
Dendritic spines, the actin-rich protrusions emerging from dendrites, are the locations of excitatory synapses in mammalian…
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Highly Cited
2008
Highly Cited
2008
The proteome profile of the human osteosarcoma U2OS cell line.
K. Niforou
,
A. Anagnostopoulos
,
K. Vougas
,
C. Kittas
,
V. Gorgoulis
,
G. Tsangaris
Cancer Genomics & Proteomics
2008
Corpus ID: 23912080
The human osteosarcoma U2OS cell line is one of the first generated cell lines and is used in various areas of biomedical…
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Review
2008
Review
2008
A new role for cortactin in invadopodia: regulation of protease secretion.
E. Clark
,
Alissa M. Weaver
European Journal of Cell Biology
2008
Corpus ID: 34030571
2007
2007
Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP
V. Cantarelli
,
T. Kodama
,
+5 authors
T. Honda
Cellular Microbiology
2007
Corpus ID: 25270032
Enterohaemorrhagic Escherichia coli (EHEC) is an important food‐borne pathogen that, upon infection, causes destruction of the…
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Highly Cited
2003
Highly Cited
2003
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Julie A Head
,
Dongyang Jiang
,
+4 authors
S. Weed
Molecular Biology of the Cell
2003
Corpus ID: 8344053
Cortactin is an F-actin binding protein that activates actin-related protein 2/3 complex and is localized within lamellipodia…
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Highly Cited
2003
Highly Cited
2003
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
P. Hou
,
L. Estrada
,
Andrew W. Kinley
,
J. Parsons
,
A. Vojtek
,
J. Gorski
Human Molecular Genetics
2003
Corpus ID: 16896441
FGD1 mutations result in Faciogenital Dysplasia (FGDY), an X-linked human disease that affects skeletal formation and embryonic…
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Highly Cited
2003
Highly Cited
2003
Alternative Splicing of the Actin Binding Domain of Human Cortactin Affects Cell Migration*
A. V. van Rossum
,
J. de Graaf
,
+5 authors
E. Schuuring
Journal of Biological Chemistry
2003
Corpus ID: 20295167
Cortactin is a filamentous actin (F-actin)-binding protein that regulates cytoskeletal dynamics by activating the Arp2/3 complex…
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Highly Cited
1999
Highly Cited
1999
An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation
E. Bowden
,
Mara Barth
,
D. Thomas
,
R. Glazer
,
S. Mueller
Oncogene
1999
Corpus ID: 23991611
Invasive breast cancer cells have the ability to extend membrane protrusions, invadopodia, into the extracellular matrix (ECM…
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Highly Cited
1999
Highly Cited
1999
Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
D. H. Campbell
,
R. Sutherland
,
R. Daly
Cancer Research
1999
Corpus ID: 16756609
The structural characteristics of EMS1 (human cortactin) suggest that it may link signaling events to reorganization of the actin…
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Highly Cited
1998
Highly Cited
1998
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
S. Weed
,
Yunrui Du
,
J. Parsons
Journal of Cell Science
1998
Corpus ID: 12775308
Small GTPases of the Rho family regulate signaling pathways that control actin cytoskeletal structures. In Swiss 3T3 cells, RhoA…
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