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CTTN protein, human

Known as: Amplaxin, Oncogene EMS1, EMS1 
Src substrate cortactin (550 aa, ~62 kDa) is encoded by the human CTTN gene. This protein is involved in the regulation of both the interactions… 
National Institutes of Health

Related topics

Related topics

14 relations
Actin-Binding ProteinAgrin PathwayCTTN geneCTTN wt Allele

Broader (1)

Cortactin

Papers overview

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Highly Cited
2012
Highly Cited
2012
Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance
Dendritic spines, the actin-rich protrusions emerging from dendrites, are the locations of excitatory synapses in mammalian… 
2012
2012
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ
Objective Cortactin acts as a prominent substrate of histone deacetylases (HDACs) and plays important roles in tumour progression… 
Highly Cited
2008
Highly Cited
2008
The proteome profile of the human osteosarcoma U2OS cell line.
The human osteosarcoma U2OS cell line is one of the first generated cell lines and is used in various areas of biomedical… 
Review
2008
Review
2008
A new role for cortactin in invadopodia: regulation of protease secretion.
2007
2007
Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP
Enterohaemorrhagic Escherichia coli (EHEC) is an important food‐borne pathogen that, upon infection, causes destruction of the… 
Highly Cited
2003
Highly Cited
2003
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Cortactin is an F-actin binding protein that activates actin-related protein 2/3 complex and is localized within lamellipodia… 
Highly Cited
2003
Highly Cited
2003
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
FGD1 mutations result in Faciogenital Dysplasia (FGDY), an X-linked human disease that affects skeletal formation and embryonic… 
Highly Cited
1999
Highly Cited
1999
An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation
Invasive breast cancer cells have the ability to extend membrane protrusions, invadopodia, into the extracellular matrix (ECM… 
Highly Cited
1999
Highly Cited
1999
Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
The structural characteristics of EMS1 (human cortactin) suggest that it may link signaling events to reorganization of the actin… 
Highly Cited
1998
Highly Cited
1998
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
Small GTPases of the Rho family regulate signaling pathways that control actin cytoskeletal structures. In Swiss 3T3 cells, RhoA… 
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