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CTGF gene

Known as: IGFBP8, CONNECTIVE TISSUE GROWTH FACTOR, Connective Tissue Growth Factor Gene 
This gene is involved in mitogenesis.
National Institutes of Health

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CTGF wt Allele
Cell Differentiation processCell Proliferation Regulatory ProcessHomo sapiensReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Cardiovascular disease, nervous system disorders, and cancer in association with other diseases such as diabetes mellitus result… 
Highly Cited
2012
Highly Cited
2012
Aldosterone Inhibits Antifibrotic Factors in Mouse Hypertensive Heart
The renin-angiotensin-aldosterone system is involved in the arterial hypertension-associated cardiovascular remodeling. In this… 
Highly Cited
2012
Highly Cited
2012
CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGF&bgr; type II receptor with implications for nephropathic cell phenotypes
Summary Signalling interplay between transforming growth factor-&bgr; (TGF&bgr;) and CCN2 [also called connective tissue growth… 
Highly Cited
2009
Highly Cited
2009
Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts
Background Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which… 
Highly Cited
2006
Highly Cited
2006
Expression and regulation of connective tissue growth factor by transforming growth factor β and tumour necrosis factor α in fibroblasts isolated from strictures in patients with Crohn's disease
Connective tissue growth factor (CTGF) stimulates fibroblast proliferation and extracellular matrix production. Fibroblasts may… 
Highly Cited
2006
Highly Cited
2006
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Highly Cited
2005
Highly Cited
2005
Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.
OBJECTIVE To investigate expression of the chemokine receptor CCR2 on key cell types involved in the pathogenesis of systemic… 
Highly Cited
2005
Highly Cited
2005
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
Osteoarthritis (OA), the commonest form of arthritis and a major cause of morbidity, is characterized by progressive degeneration… 
Highly Cited
2001
Highly Cited
2001
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts.
It is possible that many of the fibrogenic effects of transforming growth factor-beta (TGF-beta) are mediated by connective… 
Highly Cited
1998
Highly Cited
1998
Erratum: Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPS): Characterization of connective tissue growth factor as a member of the IGFBP superfamily…
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