• Publications
  • Influence
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
TLDR
It is concluded that enlargement of the CAG repeat in the androgen receptor gene is probably the cause of X-LINKED spinal and bulbar muscular atrophy.
Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist
TLDR
It is reported that the major and persistent DDT metabolite,P,P′-DDE (l,l-dichloro-2,2-bis(P- chlorophenyl)ethylene), has little ability to bind the oestrogen receptor, but inhibits androgen binding to the androgen receptor.
Androgen receptor defects : Historical, clinical, and molecular perspectives
TLDR
AIS is an archetypal example of a hormone resistance disorder; however, due to defective androgen receptor (AR1) function, there is loss of target organ response to the hormone, and the effects of androgens are reduced or absent.
The Androgen Axis in Recurrent Prostate Cancer
TLDR
Novel therapies for recurrent prostate cancer should target androgen receptor directly and prevent the formation of androgens within prostate cancer tissue at levels sufficient to activate androgenceptor.
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
TLDR
The results suggest that AR is transcriptionally active in recurrent CaP and can increase cell proliferation at the low circulating levels of androgen reported in castrated men.
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
TLDR
A majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptors coactivator 1, and this work provides a molecular basis for this activation and suggests a general mechanism for recurrent prostate cancer growth.
Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
The insulin-like growth factor (IGF) binding proteins (IGFBPs) modulate the actions of the insulin-like growth factors in endocrine, paracrine, and autocrine settings. Additionally, some IGFBPs
...
...