Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
It is concluded that enlargement of the CAG repeat in the androgen receptor gene is probably the cause of X-LINKED spinal and bulbar muscular atrophy.
Persistent DDT metabolite p,p'DDE is a potent androgen receptor antagonist
- W. Kelce, Christy R. Stone, S. Laws, L. Gray, J. A. Kemppainen, E. Wilson
- Biology, ChemistryNature
- 15 June 1995
It is reported that the major and persistent DDT metabolite,P,P′-DDE (l,l-dichloro-2,2-bis(P- chlorophenyl)ethylene), has little ability to bind the oestrogen receptor, but inhibits androgen binding to the androgen receptor.
Androgen receptor defects : Historical, clinical, and molecular perspectives
- C. Quigley, A. Bellis, K. Marschke, M. El-Awady, E. Wilson, F. S. French
- Medicine, Biology
- 1 June 1995
AIS is an archetypal example of a hormone resistance disorder; however, due to defective androgen receptor (AR1) function, there is loss of target organ response to the hormone, and the effects of androgens are reduced or absent.
Androgen receptor defects: historical, clinical, and molecular perspectives.
The Androgen Axis in Recurrent Prostate Cancer
Novel therapies for recurrent prostate cancer should target androgen receptor directly and prevent the formation of androgens within prostate cancer tissue at levels sufficient to activate androgenceptor.
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
The results suggest that AR is transcriptionally active in recurrent CaP and can increase cell proliferation at the low circulating levels of androgen reported in castrated men.
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
A majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptors coactivator 1, and this work provides a molecular basis for this activation and suggests a general mechanism for recurrent prostate cancer growth.
Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
- H. Kim, S. Nagalla, Y. Oh, E. Wilson, C. Roberts, R. Rosenfeld
- BiologyProceedings of the National Academy of Sciences…
- 25 November 1997
The insulin-like growth factor (IGF) binding proteins (IGFBPs) modulate the actions of the insulin-like growth factors in endocrine, paracrine, and autocrine settings. Additionally, some IGFBPs…
A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences.