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CSL360

Known as: Anti-CD123 Monoclonal Antibody CSL360 
A chimeric IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain) with potential antineoplastic activity. Derived from mouse… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Monoclonal Antibodies
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.
2014
2014
MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLS-CSL360 radioimmunoconjugates recognizing the CD123+ / CD131- epitope…
2012
2012
Engineering a CD 123 xCD 3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
Engineered bispecific antibodies that recruit cytotoxic lymphocytes to kill specific tumor cells have been showing promising… 
2010
2010
A phase I study of anti-CD123 monoclonal antibody (mAb) CSL360 targeting leukemia stem cells (LSC) in AML.
e13012 Background: Eradication of LSC is a goal of anti-leukemic therapy. AML LSC found in CD34+CD38- cell fractions express high… 
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