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CSK protein, human

Known as: Protein-Tyrosine Kinase CYL, EC 2.7.1.112, CSK Protein Kinase 
Tyrosine-protein kinase CSK (450 aa, ~51 kDa) is encoded by the human CSK gene. This protein plays a role in tyrosine phosphorylation, signal… 
National Institutes of Health

Related topics

Related topics

24 relations
B Cell Receptor Signaling PathwayCSK geneCell Cycle ControlCell Differentiation process

Broader (2)

Protein Tyrosine Kinaseprotein-tyrosine kinase c-src

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
LYP inhibits T cell activation when dissociated from CSK
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T… 
Highly Cited
2012
Highly Cited
2012
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B cell signaling and activation
The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify… 
Highly Cited
2008
Highly Cited
2008
The ancestral symbiont sensor kinase CSK links photosynthesis with gene expression in chloroplasts
We describe a novel, typically prokaryotic, sensor kinase in chloroplasts of green plants. The gene for this chloroplast sensor… 
Review
2005
Review
2005
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)—endogenous negative regulators of Src-family protein kinases
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are endogenous inhibitors of the Src-family protein tyrosine kinases… 
Review
2002
Review
2002
Models of cytoskeletal mechanics of adherent cells
Abstract Adherent cells sense their mechanical environment, which, in turn, regulates their functions. During the past decade, a… 
Highly Cited
1999
Highly Cited
1999
The role of prestress and architecture of the cytoskeleton and deformability of cytoskeletal filaments in mechanics of adherent cells: a quantitative analysis.
Mechanical properties of adherent cells were investigated using methods of engineering mechanics. The cytoskeleton (CSK) was… 
Highly Cited
1995
Highly Cited
1995
The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src
CSK is a predominantly cytosolic protein-tyrosine kinase (PTK) that negatively regulates Src family PTKs by phosphorylation of a… 
Highly Cited
1995
Highly Cited
1995
35H, a Sequence Isolated as a Protein Kinase C Binding Protein, Is a Novel Member of the Adducin Family (*)
We recently cloned a partial cDNA (35H) for a protein kinase C (PKC) binding protein from a rat kidney cDNA library and… 
Highly Cited
1993
Highly Cited
1993
Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae
The kinase activity of c-Src is normally repressed in vertebrate cells by extensive phosphorylation of Y-527. C-terminal Src… 
Highly Cited
1991
Highly Cited
1991
CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
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