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CRYAA gene

Known as: CRYSTALLIN, ALPHA-1, CRYA1, crystallin alpha A 
National Institutes of Health

Related topics

Related topics

2 relations
CATARACT, AUTOSOMAL RECESSIVE, EARLY-ONSET, PULVERULENTalpha-Crystallin A Chain

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Long Non-Coding RNA H19 Regulates Human Lens Epithelial Cells Function
Background/Aims: Age-related cataract (ARC) remains the leading cause of visual impairment among the elderly population. Long non… 
Highly Cited
2011
Highly Cited
2011
Mutation analysis of 12 genes in Chinese families with congenital cataracts
Purpose To identify mutations in 12 genes in Chinese families with congenital cataracts. Methods Twenty five families with… 
2010
2010
Autosomal Dominant Congenital Nuclear Cataracts Caused by a CRYAA Gene Mutation
Purpose: We sought to identify the genetic defect in a four-generation Chinese family with autosomal dominant congenital nuclear… 
2009
2009
Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R αA-crystallin
Purpose: Crystallins are major functional and structural proteins in mammalian lens. Their expression, distribution, and protein… 
Highly Cited
2008
Highly Cited
2008
Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA)
We studied 28 individuals from a four‐generation Chilean family (ADC54) including 13 affected individuals with cataracts… 
2008
2008
Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: Potential vulnerability to oxidative stress
PurposeTo investigate global protein expression profiles in the retinas of normal and glucocorticoid-induced ocular hypertensive… 
Highly Cited
2007
Highly Cited
2007
Recessive congenital total cataract with microcornea and heterozygote carrier signs caused by a novel missense CRYAA mutation (R54C).
Highly Cited
2006
Highly Cited
2006
Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family.
PURPOSE The aim of the present study was to investigate the molecular basis underlying a nonsyndromic presenile autosomal… 
1989
1989
Gene dosage effect on the expression of the delta-endotoxin genes of Bacillus thuringiensis subsp. kurstaki in Bacillus subtilis and Bacillus megaterium.
1987
1987
Confirmation of assignment of the human α1-crystallin gene (CRYA1) to chromosome 21 with regional localization to q22.3
SummaryThe crystallins are highly conserved structural proteins universally found in the eye lens of all vertebrate species. In… 
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