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HTRA1 promoter polymorphism in wet age-related macular degeneration.
Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular).… Expand
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
OBJECTIVE To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure-function… Expand
SLC4A11 mutations in Fuchs endothelial corneal dystrophy.
The endothelial (posterior) corneal dystrophies, which result from primary endothelial dysfunction, include Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD)… Expand
Comparison of macular thickness measurements between time domain and spectral domain optical coherence tomography.
- C. Leung, C. Cheung, +4 authors D. Lam
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 November 2008
PURPOSE To compare macular thickness measurements obtained from time domain optical coherence tomography (OCT) and spectral domain OCT and to evaluate their repeatability and agreement. METHODS… Expand
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that… Expand
Gene mapping for primary open angle glaucoma.
Primary open angle glaucoma (POAG) is a leading cause of visual impairment and blindness worldwide. To date, at least 20 genetic loci for POAG have been reported. Only 3 causative genes are… Expand
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
- G. Thorleifsson, G. Walters, +44 authors K. Stefánsson
- Medicine, Biology
- Nature Genetics
- 1 October 2010
We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at… Expand
Association of complement factor H polymorphisms with exudative age-related macular degeneration.
PURPOSE Variants in the complement factor H (CFH) gene have been reported to be associated with age-related macular degeneration (AMD). We conducted a case-control association study to investigate… Expand
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China. We observed genome-wide… Expand
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium… Expand