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Data from murine models suggest that CD40 activation may synergize with cytotoxic chemotherapy. We aimed to determine… Expand Purpose: This phase I study investigated the maximum-tolerated dose (MTD), safety, pharmacodynamics, immunologic correlatives… Expand CD40 is a cell-surface molecule that critically regulates immune responses. CP-870,893 is a fully human, CD40-specific agonist… Expand CD40 is a member of the TNF family of receptors that has been shown to play a crucial role in enhancing dendritic cell activity… Expand Anti-CD40 antibodies are in clinical development in patients with metastatic melanoma, a cancer that has been reported earlier to… Expand BackgroundCD40 activation of antigen presenting cells (APC) such as dendritic cells (DC) and B cells plays an important role in… Expand PURPOSE
The cell-surface molecule CD40 activates antigen-presenting cells and enhances immune responses. CD40 is also expressed… Expand 2507 Background: The cell-surface molecule CD40 plays a critical role in activating antigen presenting cells (APC) and mediates… Expand 2514 Background: CP-870,893 is a fully human IgG2 CD40 agonist antibody currently in early clinical trials. In vitro studies… Expand 2539 Background: CD40 is expressed on B-cells, monocytes, dendritic cells, other normal tissues and tumors. Previous studies… Expand