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CORVET complex

Known as: CORVET complex location 
A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2017
02420072017

Papers overview

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2018
2018
Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions
Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and cytokinesis. Yet… (More)
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2017
2017
Disruption of genes involved in CORVET complex leads to enhanced secretion of heterologous carboxylesterase only in protease deficient Pichia pastoris.
The methylotrophic yeast Pichia pastoris (Komagataella spp.) is a popular microbial host for the production of recombinant… (More)
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2013
2013
The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.
Membrane fusion along the endocytic pathway occurs in a sequence of tethering, docking, and fusion. At endosomes and vacuoles… (More)
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2013
2013
The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes
Endosomal biogenesis depends on multiple fusion and fission events. For fusion, the heterohexameric CORVET complex as an effector… (More)
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2013
2013
Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes
Biochemical and structural analysis of macromolecular protein assemblies remains challenging due to technical difficulties in… (More)
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2013
2013
Comparative Genomic Analysis of Multi-Subunit Tethering Complexes Demonstrates an Ancient Pan-Eukaryotic Complement and Sculpting in Apicomplexa
Apicomplexa are obligate intracellular parasites that cause tremendous disease burden world-wide. They utilize a set of… (More)
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2012
2012
The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles
Fusion of organelles in the endomembrane system depends on Rab GTPases that interact with tethering factors before lipid bilayer… (More)
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Review
2011
Review
2011
Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs.
Membrane fusion at late endosomes and vacuoles depends on a conserved machinery, which includes Rab GTPases, their binding to… (More)
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2009
2009
The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.
Membrane tethering, the process of mediating the first contact between membranes destined for fusion, requires specialized… (More)
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Highly Cited
2007
Highly Cited
2007
The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.
The dynamic equilibrium between vesicle fission and fusion at Golgi, endosome, and vacuole/lysosome is critical for the… (More)
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