Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions

@article{Jonker2018Vps3AV,
  title={Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions},
  author={C T H Jonker and Romain Galmes and Tineke Veenendaal and Corlinda B ten Brink and Reini E N van der Welle and Nalan Liv and Johan de Rooij and Andrew A. Peden and Peter van der Sluijs and Coert Margadant and Judith Klumperman},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and cytokinesis. Yet, the molecular machineries that drive endocytic recycling remain largely unclear. The CORVET complex is a multi-subunit tether required for fusion between early endosomes. Here we show that the CORVET-specific subunits Vps3 and Vps8 also regulate vesicular transport from early to recycling endosomes. Vps3 and Vps8 localise to Rab4-positive recycling vesicles and co… 
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