Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions

@article{Jonker2018Vps3AV,
  title={Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions},
  author={C T H Jonker and Romain Galmes and Tineke Veenendaal and Corlinda B ten Brink and Reini E N van der Welle and Nalan Liv and Johan de Rooij and Andrew A. Peden and Peter van der Sluijs and Coert Margadant and Judith Klumperman},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and cytokinesis. Yet, the molecular machineries that drive endocytic recycling remain largely unclear. The CORVET complex is a multi-subunit tether required for fusion between early endosomes. Here we show that the CORVET-specific subunits Vps3 and Vps8 also regulate vesicular transport from early to recycling endosomes. Vps3 and Vps8 localise to Rab4-positive recycling vesicles and co… 
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How INVs may integrate into established membrane trafficking pathways using integrin recycling as an example is discussed and where in the cell INVs have the potential to operate is speculated.
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Pathways of integrins in the endo-lysosomal system.
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This review presents recent scientific advances about integrin trafficking in the endo-lysosomal system, and reviews the internalization and recycling pathways of integrins, and provides information about the possible ways of lysosomal degradation through the endosomal and autophagic system.
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References

SHOWING 1-10 OF 71 REFERENCES
PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading
PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading.
TLDR
It is proposed that growth factor-regulated, rab4-dependent recycling of alphavbeta3 integrin from early endosomes to the plasma membrane is a critical upstream event in the assembly of cell-matrix contacts.
The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway
Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression
Endocytosed Transferrin Receptors Recycle via Distinct Dynamin and Phosphatidylinositol 3-Kinase-dependent Pathways*
TLDR
Two distinct recycling pathways are shown, one of which involves transfer from early endosomes to recycling endOSomes, from where clathrin/dynamin-coated vesicles provide for further transport, whereas the other route bypasses recycling endosome and requires phosphatidylinositol 3-kinase activity.
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
TLDR
The discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval and recycling and, importantly, is biochemically and functionally distinct from the established retromer pathway is described.
Distinct Recycling of Active and Inactive β1 Integrins
TLDR
The endocytic trafficking of active and inactive β1 integrins in cancer cells is investigated and the possibility of a previously unappreciated crosstalk between pathways regulating integrin activity and traffic is implied.
Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes.
TLDR
The incapacity of the constitutively active form of rab11 (Q70L) to inhibit recycling of molecules interiorized at 16 degreesC is consistent with their recycling taking place directly from sorting endosomes, in a process that does not require hydrolysis of GTP on rab11.
Tethering complexes in the endocytic pathway: CORVET and HOPS
TLDR
Accumulating evidence supports the view that endosomal tethering complexes implement a regulatory logic that governs endomembrane identity and dynamics and suggests an intricate cooperative network for endosome maturation.
Rab4 affects both recycling and degradative endosomal trafficking
...
...