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CHS 828

Known as: CHS828, N-(6-(4-Chlorophenoxy)hexyl)-N'-Cyano-N''-4-Pyridylcyanoguanidine, CHS-828 
A pyridyl cyanoguanidine that exhibits antitumor activity by an unknown mechanism. (NCI)
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2014
Highly Cited
2014
Factors Associated with the Occurrence of Cardiac Arrest after Emergency Tracheal Intubation in the Emergency Department
Objectives Emergency tracheal intubation has achieved high success and low complication rates in the emergency department (ED… 
Review
2013
Review
2013
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.
Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment of the NAD pool in cells. This in turn… 
Review
2010
Review
2010
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data
PurposeDepletion of cellular nicotinamide adenine dinucleotide (NAD) by inhibition of its synthesis is a new pharmacological… 
Highly Cited
2007
Highly Cited
2007
Functional analysis of soybean genes involved in flavonoid biosynthesis by virus-induced gene silencing.
Virus-induced gene silencing (VIGS) is a powerful tool for functional analysis of genes in plants. A wide-host-range VIGS vector… 
Highly Cited
2003
Highly Cited
2003
Anxiety disorders in subjects seeking treatment for eating disorders: a DSM-IV controlled study
Highly Cited
2002
Highly Cited
2002
A Phase I study of CHS 828 in patients with solid tumor malignancy.
CHS 828 is a cyanoguanidine, which has demonstrated potent antitumor activity in preclinical tumor models. The activity of CHS… 
Highly Cited
2001
Highly Cited
2001
Interactions within a network of phytochrome, cryptochrome and UV-B phototransduction pathways regulate chalcone synthase gene expression in Arabidopsis leaf tissue.
The Arabidopsis gene encoding the key flavonoid biosynthesis enzyme chalcone synthase (CHS) is regulated by several environmental… 
Highly Cited
1999
Highly Cited
1999
CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.
A new class of recently discovered antineoplastic agents, the pyridyl cyanoguanidines, exert a potent antitumor activity in… 
Highly Cited
1994
Highly Cited
1994
Cyclic GMP and calcium mediate phytochrome phototransduction
Highly Cited
1989
Highly Cited
1989
The chalcone synthase multigene family of Petunia hybrida (V30): differential, light-regulated expression during flower development and UV light induction
We have analysed the expression of the 8–10 members of the gene family encoding the flavonoid biosynthetic enzyme chalcone… 
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