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CHKA wt Allele

Known as: Choline Kinase Gene, CKI, CHETK-Alpha Gene 
Human CHKA wild-type allele is located in the vicinity of 11q13.2 and is approximately 69 kb in length. This allele, which encodes choline kinase… 
National Institutes of Health

Related topics

Related topics

11 relations
11q13.1Breast CarcinomaCHKA protein, humanCarcinoma of lung

Broader (2)

CHKA geneCholine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Genetic parameters for yearling weight, carcass traits, and primal-cut yields of Hanwoo cattle.
Genetic parameters associated with yearling weight, carcass traits, and primal-cut yields of male Hanwoo cattle were investigated… 
2014
2014
CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells
BackgroundAcute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment… 
Highly Cited
2012
Highly Cited
2012
Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells
CHK1 and CHK2 function as effectors of cell cycle checkpoint arrest following DNA damage. Small molecule inhibitors of CHK… 
Highly Cited
2005
Highly Cited
2005
Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.
Highly Cited
2003
Highly Cited
2003
Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells
Cancer treatment is in the need of selective drugs that can interfere specifically with signalling pathways affected during the… 
2001
2001
Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
An increasing amount of evidence suggests that elevated PCho levels are related to the transforming properties of the H-Ras… 
2001
2001
Functional Analysis of Csk and CHK Kinases in Breast Cancer Cells*
In this report, we analyzed the expression and kinase activities of Csk and CHK kinases in normal breast tissues and breast… 
Highly Cited
2001
Highly Cited
2001
Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics.
The Csk family of non-receptor-type tyrosine kinases consists of Csk and the Csk homologous kinase Chk. Each enzyme suppresses… 
Highly Cited
2000
Highly Cited
2000
Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure.
BACKGROUND Tissue kallikrein cleaves kininogen substrate to produce the potent vasodilating peptide kinin, which plays important… 
1999
1999
Adenovirus-mediated kallikrein gene delivery reduces aortic thickening and stroke-induced death rate in Dahl salt-sensitive rats.
BACKGROUND AND PURPOSE Kallikrein gene delivery has been shown to attenuate hypertension, cardiac hypertrophy, and renal injury… 
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