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CHKA protein, human

Known as: CKI, CHOK, Choline Kinase Alpha 
Choline kinase alpha (457 aa, ~52 kDa) is encoded by the human CHKA gene. This protein plays a role in phospholipid biosynthesis.
National Institutes of Health

Related topics

Related topics

13 relations
Breast CarcinomaCHKA geneCHKA wt AlleleCarcinoma of lung

Broader (1)

Choline Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Phosphocholine as a biomarker of breast cancer: Molecular and biochemical studies
The discovery of metabolic and molecular markers that help improving the detection and diagnosis of breast cancer is an important… 
Highly Cited
2006
Highly Cited
2006
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
p27kip1, a cyclin-dependent kinase (CDK) inhibitor (CKI), generally suppresses CDK activity in proliferating cells. Although… 
Highly Cited
2003
Highly Cited
2003
A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling
Highly Cited
2002
Highly Cited
2002
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
Highly Cited
2002
Highly Cited
2002
Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells
ABSTRACT Recent studies have shown that casein kinase I ε (CKIε) is an essential regulator of the mammalian circadian clock… 
Highly Cited
2002
Highly Cited
2002
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.
Highly Cited
2001
Highly Cited
2001
Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
UNLABELLED Elevated levels of choline (trimethyl-2-hydroxyethylammonium) and choline kinase (CK) activity in neoplasms have… 
Highly Cited
1999
Highly Cited
1999
Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1
Cyclin E–Cdk2 kinase activation is an essential step in Myc‐induced proliferation. It is presumed that this requires… 
Highly Cited
1998
Highly Cited
1998
Expression of cyclin-dependent kinase inhibitors in vascular disease.
Arterial lesions in cardiovascular diseases are characterized by proliferation and migration of smooth muscle cells as well as… 
Highly Cited
1997
Highly Cited
1997
Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast.
Cyclin-dependent kinase inhibitors (CKIs) play key roles in controlling the eukaryotic cell cycle by coordinating cell… 
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