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CHKA protein, human

Known as: CKI, CHOK, Choline Kinase Alpha 
Choline kinase alpha (457 aa, ~52 kDa) is encoded by the human CHKA gene. This protein plays a role in phospholipid biosynthesis.
National Institutes of Health

Related topics

Related topics

13 relations
Breast CarcinomaCHKA geneCHKA wt AlleleCarcinoma of lung

Broader (1)

Choline Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor.
Applying a CHOK hold: Combined experimental and computational studies of the binding mode of a rationally designed inhibitor of… 
2006
2006
Molecular characterization and localization of Plasmodium falciparum choline kinase.
Highly Cited
2005
Highly Cited
2005
Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells.
Toward the goal of developing effective treatments for prostate cancers, we examined the effects of cyclin-dependent kinase… 
Review
1997
Review
1997
The regulation of cyclin-dependent kinase inhibitors (CKIs).
Inhibitors of cyclin-dependent kinases (CKIs) play key roles in coordinating cell proliferation and development. They also… 
1994
1994
Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in…
It has been established that yeast membrane phospholipid content is responsive to the inositol and choline content of the growth… 
1994
1994
N-[2-bromocinnamyl(amino)ethyl]-5-isoquinolinesulphonamide (H-89) inhibits incorporation of choline into phosphatidylcholine via inhibition of choline kinase and has no effect on the phosphorylation…
We have shown previously that N-[2-bromocinnamyl(amino)-ethyl]-5-isoquinolinesulphonamide (H-89), a selective inhibitor of cyclic… 
1992
1992
The in vitro phosphorylation of the native rat incisor dentin phosphophoryns.
1986
1986
Several lines of evidence demonstrating that Plasmodium falciparum, a parasitic organism, has distinct enzymes for the phosphorylation of choline and ethanolamine
1985
1985
Evidence for the existence of multiple forms of choline (ethanolamine) kinase in rat tissues.
1979
1979
Lipid metabolism in germinating seeds. Purification of ethanolamine kinase from soya bean.
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