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CHI3L1 protein, human

Known as: YKL40 protein, human, human cartilage gp39, YKL-40 protein, human 
A substance that may be found in higher-than-normal amounts in the blood of patients with certain types of cancer and inflammatory diseases. It is a… 
National Institutes of Health

Related topics

Related topics

16 relations
CHI3L1 geneChondrocyteCytoplasmExtracellular Space

Broader (2)

Chitinase-3-Like Protein 1Growth Substances

Narrower (1)

Chondrex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma.
Highly Cited
2012
Highly Cited
2012
YKL-40 Induces IL-8 Expression from Bronchial Epithelium via MAPK (JNK and ERK) and NF-κB Pathways, Causing Bronchial Smooth Muscle Proliferation and Migration
Recently, the serum levels of YKL-40, a chitinase-like glycoprotein, have been shown to be significantly elevated in asthmatics… 
Highly Cited
2011
Highly Cited
2011
A YKL-40–Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers
Accumulating evidence has indicated that expression levels of YKL-40, a secreted glycoprotein, were elevated in multiple advanced… 
Highly Cited
2004
Highly Cited
2004
High serum YKL-40 level in patients with small cell lung cancer is related to early death.
Highly Cited
2003
Highly Cited
2003
High Serum YKL-40 Levels in Patients with Primary Breast Cancer is Related to Short Recurrence Free Survival
YKL-40 is a growth factor for connective tissue cells and stimulates migration of endothelial cells. YKL-40 is secreted by cancer… 
Highly Cited
2002
Highly Cited
2002
Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma.
We have identified a potential serum marker for glioblastoma multiforme (GBM) using microarray analysis from samples of GBM. We… 
Highly Cited
2000
Highly Cited
2000
Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis.
Considerable evidence indicates that CD4(+) T cells are important in the pathogenesis of rheumatoid arthritis (RA), but the… 
Highly Cited
1999
Highly Cited
1999
Serum YKL-40 and colorectal cancer
SummaryYKL-40 is a mammalian member of the chitinase protein family. Although the function of YKL-40 is unknown, the pattern of… 
Highly Cited
1996
Highly Cited
1996
Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint.
YKL-40 is a recently discovered human glycoprotein which is related in amino acid sequence to the chitinase protein family. YKL… 
Highly Cited
1995
Highly Cited
1995
Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer.
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