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CHD8 gene

Known as: KIAA1564, AXIS DUPLICATION INHIBITOR, CHD8 
This gene plays a role in both chromatin remodeling and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

13 relations
ATP HydrolysisCHD8 protein, humanDNA RepairDNA Replication

Narrower (1)

CHD8 wt Allele

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
Nearly all patients with small cell lung cancer (SCLC) eventually relapse with chemoresistant disease. The molecular mechanisms… 
Highly Cited
2017
Highly Cited
2017
The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities
Proper chromatin regulation is central to genome function and maintenance. The group III chromodomain–helicase–DNA-binding (CHD… 
Highly Cited
2015
Highly Cited
2015
NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
Highly Cited
2015
Highly Cited
2015
The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes
Chromodomain helicase DNA-binding protein 8 (CHD8) was identified as a leading autism spectrum disorder (ASD) candidate gene by… 
Highly Cited
2013
Highly Cited
2013
The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes
The precise regulation of S-phase–specific genes is critical for cell proliferation. How the repressive chromatin configuration… 
Highly Cited
2011
Highly Cited
2011
Genetic and expressional alterations of CHD genes in gastric and colorectal cancers
Kim M S, Chung N G, Kang M R, Yoo N J & Lee S H
(2011) Histopathology58, 660–668
Genetic and expressional alterations of CHD… 
Highly Cited
2009
Highly Cited
2009
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
The chromodomain helicase DNA-binding (CHD) family of enzymes is thought to regulate gene expression, but their role in the… 
Highly Cited
2009
Highly Cited
2009
The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene
CHD8 is a chromatin remodeling ATPase of the SNF2 family. We found that depletion of CHD8 impairs cell proliferation. In order to… 
Highly Cited
2006
Highly Cited
2006
CTCF-dependent chromatin insulator is linked to epigenetic remodeling.
Review
2002
Review
2002
CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases
Chromosomal DNA of eukaryotic cells is functionally organized by complex formation with nuclear proteins in chromatin… 
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