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A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.
- Penka S. Petrova, A. Raibekas, J. Commissiong
- BiologyJournal of molecular neuroscience : MN
- 1 April 2003
The selective, neuroprotective effect of MANF for dopaminergic neurons suggests that it may be indicated for the treatment of Parkinson's disease.
Loss of HSulf-1 Up-regulates Heparin-binding Growth Factor Signaling in Cancer*
Observations provide evidence that HSulf-1 modulates signaling by heparin-binding growth factors, and HS sulfur-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling.
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
Observations raise the possibility of HtrA1 as a candidate tumor suppressor involved in promoting serine-protease-mediated cell death and that downregulation of HTRA1 in ovarian cancer may contribute to malignant phenotype.
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.
Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis and the effect of the DNA methylation inhibitor 5-aza-deoxycytidine on hS sulfur1 expression is investigated.
HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma
The data suggest that HSulf-1 normally functions as a negative regulator in cell growth and loss of HS sulfur-1 in SCCHN potentiates growth factor signaling, enhances motility, invasiveness and inhibits stress-induced apoptosis, with a resulting increase in tumorigenecity.
HSulf-1 inhibits angiogenesis and tumorigenesis in vivo.
It is reported that HSulf-1 expression in MDA-MB-468 breast carcinoma clonal lines leads to reduced proliferation in vitro and reduced tumor burden in athymic nude mice in vivo and provides the first evidence of a novel mechanism by which HS sulfur-1 modulates the function of heparan sulfate binding VEGF165 in proliferation and angiogenesis.
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
The findings uncover what they believe to be a novel pathway by which serine protease HtrA1 mediates paclitaxel- and cisplatin-induced cytotoxicity and suggest that loss of Htr a1 in ovarian and gastric cancers may contribute to in vivo chemoresistance.
Simian virus-40 large-T antigen binds p53 in human mesotheliomas
It is found that simian virus 40 (SV40) induces mesotheliomas in hamsters and that 60% of human mesotheiiomas contain and express SV40 sequences2 and that SV40 Tag retains its ability to bind and to inactivate p53, a cellular protein that when normally expressed plays an important role in suppressing tumor growth and in inducing sensitivity to therapy.
Implications of the serine protease HtrA1 in amyloid precursor protein processing
The data suggest that HtrA1 is directly involved in the β-amyloid pathway as it degrades various fragments of amyloid precursor protein while an Htr a1 inhibitor causes accumulation of Aβ in astrocyte cell culture supernatants.