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CH5183284

National Institutes of Health

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3 relations

Broader (2)

BenzimidazolesPyrazoles

Narrower (1)

Debio 1347

Papers overview

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2018
2018
Abstract 1092: Defining the molecular phenotypes of metastatic castration-resistant prostate cancer sensitive to FGF pathway inhibition
Background: Widespread and long-term use of first-and second-line androgen-deprivation therapy (ADT) is changing the molecular… 
2017
2017
Abstract 2088: The activity of the FGFR selective inhibitor Debio 1347 is correlated with high mRNA expression
Dysregulation of the fibroblast growth factor receptor (FGFR) signaling pathway due to receptor overexpression, gene… 
2017
2017
Abstract 2076: Targeting the FGFR pathway in androgen receptor negative castration resistant prostate cancer
Metastatic castration-resistant prostate cancer (CRPC) has a poor prognosis and remains a significant therapeutic challenge. The… 
2016
2016
Abstract 4784: FGFR-selective inhibitor Debio 1347 induces tumor regressions in FGFR2-altered gastric cancer PDX models
Dysregulation of the fibroblast growth factor receptor (FGFR) signaling pathway due to receptor overexpression, gene… 
2015
2015
Preliminary clinical pharmacokinetics and pharmacodynamics of Debio 1347 (CH5183284), a novel FGFR inhibitor.
2540 Background: Deregulated fibroblast growth factor receptor (FGFR) signaling is associated with tumorigenesis. Debio 1347 is… 
2015
2015
Abstract CT228: Formulation switch and pharmacokinetics/pharmacodynamics of Debio 1347 (CH5183284), a novel FGFR inhibitor, in a first-in-human dose escalation trial in solid tumors patients
Background: Deregulated fibroblast growth factor receptor (FGFR) signaling is associated with tumorigenesis. The oral selective… 
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