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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of indolent disease also results in significant morbidity. Common geneticExpand
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EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
Alternative Role for EZH2 Epigenetic regulators are implicated in cancer progression and proposed as therapeutic targets. Xu et al. (p. 1465; see the Perspective by Cavalli) report that EZH2Expand
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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
BACKGROUND Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes amongExpand
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The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression.
Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of RB in tumorExpand
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Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
nature medicine advance online publication Personalized approaches for cancer treatment rely on the premise that defined molecular alterations in tumors will confer susceptibility to specificExpand
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Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highlyExpand
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Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Background Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reportedExpand
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Quantitative and stoichiometric analysis of the microRNA content of exosomes
Significance Exosomes have been a subject of great interest in recent years, especially in the context of the microRNAs (miRNAs) that they contain. Exosome-mediated miRNA transfer between cells hasExpand
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The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
UNLABELLED TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and inExpand
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The long tail of oncogenic drivers in prostate cancer
Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, largerExpand
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