CGS 13080

To test the role of reactive oxygen species and cyclooxygenase products in the retinal hemodynamic changes induced by asphyxia… Expand

Vascular relaxations are impaired in adult spontaneously hypertensive rats (SHRs) because of increased production of an… Expand

The endothelium releases substances controlling vascular tone and platelet function. We investigated mediators of endothelium… Expand

1 Administration of arachidonic acid caused dose‐dependent vasoconstriction in the isolated rat kidney perfused in situ with… Expand

The focus of this investigation was to examine the potential beneficial effects of the selective thromboxane synthetase inhibitor… Expand

Increase in thromboxane A2 (TXA2) generation has been proposed as a mechanism of dynamic vaso-occlusion and in vivo platelet… Expand

Abstract: CGS‐13080 is a new potent selective inhibitor of thromboxane synthetase. This study reports the results of a safety and… Expand

1 Platelet activating factor (Paf) (15–40 μg−1) kills male rabbits within 3 to 5 min. Intravenous injection of Paf at a dose of… Expand

CGS 13080 inhibited cell-free thromboxane synthetase with an IC50 of 3 nM. It was at least five orders of magnitude less potent… Expand

A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To… Expand