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CGS 13080
Known as:
CGS-13080
National Institutes of Health
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Papers overview
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Highly Cited
1993
Highly Cited
1993
Endothelium-derived contracting factors in resistance arteries of young spontaneously hypertensive rats before development of overt hypertension.
M. Jameson
,
F. Dai
,
T. Lüscher
,
J. Skopec
,
A. Diederich
,
D. Diederich
Hypertension
1993
Corpus ID: 25882178
Vascular relaxations are impaired in adult spontaneously hypertensive rats (SHRs) because of increased production of an…
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Highly Cited
1991
Highly Cited
1991
Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.
Z. Yang
,
L. V. von Segesser
,
E. Bauer
,
P. Stulz
,
M. Turina
,
T. Lüscher
Circulation research
1991
Corpus ID: 6345407
The endothelium releases substances controlling vascular tone and platelet function. We investigated mediators of endothelium…
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1989
1989
Role of endoperoxides in arachidonic acid‐induced vasoconstriction in the isolated perfused kidney of the rat
J. Quilley
,
J. Mcgiff
,
A. Nasjletti
British journal of pharmacology
1989
Corpus ID: 28702375
1 Administration of arachidonic acid caused dose‐dependent vasoconstriction in the isolated rat kidney perfused in situ with…
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1988
1988
Effect of thromboxane synthase inhibition on the thrombolytic action of tissue-type plasminogen activator in a rabbit model of peripheral arterial thrombosis.
R. Shebuski
,
B. Storer
,
T. Fujita
Thrombosis research
1988
Corpus ID: 24170440
1987
1987
Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock.
H. Bitterman
,
G. Phillips
,
G. Dragon
,
A. Lefer
The Journal of pharmacology and experimental…
1987
Corpus ID: 35398630
1986
1986
Effect of thromboxane synthetase inhibition on vulnerability to ventricular arrhythmia following coronary occlusion.
K. M. O'Connor
,
T. Friehling
,
G. Kelliher
,
M. Macnab
,
L. Wetstein
,
P. Kowey
American heart journal
1986
Corpus ID: 26917408
1985
1985
Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived…
J. Mehta
,
P. Mehta
,
D. Lawson
,
N. Ostrowski
,
L. Brigmon
The Journal of laboratory and clinical medicine
1985
Corpus ID: 295575
Increase in thromboxane A2 (TXA2) generation has been proposed as a mechanism of dynamic vaso-occlusion and in vivo platelet…
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1984
1984
The Effects of a New Thromboxane Synthetase Inhibitor, CGS‐13080, in Man
M. Macnab
,
E. Foltz
,
+4 authors
Supradip Sen
Journal of clinical pharmacology
1984
Corpus ID: 28324220
Abstract: CGS‐13080 is a new potent selective inhibitor of thromboxane synthetase. This study reports the results of a safety and…
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Highly Cited
1984
Highly Cited
1984
Pathophysiological mechanisms of sudden death induced by platelet activating factor
A. Lefer
,
H. Müller
,
J. Smith
British journal of pharmacology
1984
Corpus ID: 25726094
1 Platelet activating factor (Paf) (15–40 μg−1) kills male rabbits within 3 to 5 min. Intravenous injection of Paf at a dose of…
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1983
1983
Protection of Ischemic Cat Myocardium By CGS‐13080, a Selective Potent Thromboxane A2 Synthesis Inhibitor
S. Burke
,
G. DiCola
,
A. Lefer
Journal of cardiovascular pharmacology
1983
Corpus ID: 23781599
A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To…
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