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CGS 13080

Known as: CGS-13080 
National Institutes of Health

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Highly Cited
1993
Highly Cited
1993
Endothelium-derived contracting factors in resistance arteries of young spontaneously hypertensive rats before development of overt hypertension.
Vascular relaxations are impaired in adult spontaneously hypertensive rats (SHRs) because of increased production of an… 
Highly Cited
1991
Highly Cited
1991
Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.
The endothelium releases substances controlling vascular tone and platelet function. We investigated mediators of endothelium… 
1989
1989
Role of endoperoxides in arachidonic acid‐induced vasoconstriction in the isolated perfused kidney of the rat
1 Administration of arachidonic acid caused dose‐dependent vasoconstriction in the isolated rat kidney perfused in situ with… 
1988
1988
Effect of thromboxane synthase inhibition on the thrombolytic action of tissue-type plasminogen activator in a rabbit model of peripheral arterial thrombosis.
1987
1987
Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock.
1986
1986
Effect of thromboxane synthetase inhibition on vulnerability to ventricular arrhythmia following coronary occlusion.
1985
1985
Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived…
Increase in thromboxane A2 (TXA2) generation has been proposed as a mechanism of dynamic vaso-occlusion and in vivo platelet… 
1984
1984
The Effects of a New Thromboxane Synthetase Inhibitor, CGS‐13080, in Man
Abstract: CGS‐13080 is a new potent selective inhibitor of thromboxane synthetase. This study reports the results of a safety and… 
Highly Cited
1984
Highly Cited
1984
Pathophysiological mechanisms of sudden death induced by platelet activating factor
1 Platelet activating factor (Paf) (15–40 μg−1) kills male rabbits within 3 to 5 min. Intravenous injection of Paf at a dose of… 
1983
1983
Protection of Ischemic Cat Myocardium By CGS‐13080, a Selective Potent Thromboxane A2 Synthesis Inhibitor
A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To… 
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