CGS 13080

Known as: CGS-13080 
 
National Institutes of Health

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1995
1995
Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics.
To test the role of reactive oxygen species and cyclooxygenase products in the retinal hemodynamic changes induced by asphyxia… (More)
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1993
1993
Endothelium-derived contracting factors in resistance arteries of young spontaneously hypertensive rats before development of overt hypertension.
Vascular relaxations are impaired in adult spontaneously hypertensive rats (SHRs) because of increased production of an… (More)
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1990
1990
Lack of protective effect of thromboxane synthetase inhibitor (CGS-13080) on single dose radiated canine intestine.
The effect of a thromboxane A2 synthetase inhibitor (CGS-13080) on canine intestine was studied using a single dose of radiation… (More)
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1989
1989
Inhibition of pulmonary thromboxane A2 synthase activity and airway responses by CGS 13080
The effects of CGS 13080, a thromboxane (TXA2) synthase inhibitor, on airway responses to arachidonic acid (AA) were investigated… (More)
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1989
1989
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.
1. Administration of arachidonic acid caused dose-dependent vasoconstriction in the isolated rat kidney perfused in situ with… (More)
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1987
1987
Thromboxane synthetase inhibition with CGS 13080 improves coronary blood flow after streptokinase-induced thrombolysis.
The focus of this investigation was to examine the potential beneficial effects of the selective thromboxane synthetase inhibitor… (More)
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1985
1985
Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived…
Increase in thromboxane A2 (TXA2) generation has been proposed as a mechanism of dynamic vaso-occlusion and in vivo platelet… (More)
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1984
1984
The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man.
CGS-13080 is a new potent selective inhibitor of thromboxane synthetase. This study reports the results of a safety and efficacy… (More)
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1983
1983
Protection of ischemic cat myocardium by CGS-13080, a selective potent thromboxane A2 synthesis inhibitor.
A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To… (More)
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1983
1983
Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models.
CGS 13080 inhibited cell-free thromboxane synthetase with an IC50 of 3 nM. It was at least five orders of magnitude less potent… (More)
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