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CGS 13080

Known as: CGS-13080 
National Institutes of Health

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Highly Cited
1995
Highly Cited
1995
Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics.
To test the role of reactive oxygen species and cyclooxygenase products in the retinal hemodynamic changes induced by asphyxia… 
1995
1995
Increased thromboxane-mediated contractions of retinal vessels of newborn pigs to peroxides.
The vasomotor effects of three peroxides (H2O2, cumene hydroperoxide, and t-butyl hydroperoxide) on the retinal vasculature, as… 
Highly Cited
1989
Highly Cited
1989
Role of endoperoxides in arachidonic acid‐induced vasoconstriction in the isolated perfused kidney of the rat
1 Administration of arachidonic acid caused dose‐dependent vasoconstriction in the isolated rat kidney perfused in situ with… 
1988
1988
Effect of thromboxane synthase inhibition on the thrombolytic action of tissue-type plasminogen activator in a rabbit model of peripheral arterial thrombosis.
1988
1988
Effects of CGS-13080, a thromboxane inhibitor, on pulmonary vascular resistance in patients after mitral valve replacement surgery.
Pulmonary hypertension with an elevated pulmonary vascular resistance was observed during the immediate recovery period in… 
1988
1988
Potentiation of Myocardial Salvage by Tissue Type Plasminogen Activator in Combination With a Thromboxane Synthetase Inhibitor in Ischemic Cat Myocardium
We studied the effects of a thrombolytic agent (t-PA) and a thromboxane synthetase inhibitor (CGS-13080) in a model of myocardial… 
1986
1986
Effect of thromboxane synthetase inhibition on vulnerability to ventricular arrhythmia following coronary occlusion.
1985
1985
Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived…
Increase in thromboxane A2 (TXA2) generation has been proposed as a mechanism of dynamic vaso-occlusion and in vivo platelet… 
1983
1983
Protection of Ischemic Cat Myocardium By CGS‐13080, a Selective Potent Thromboxane A2 Synthesis Inhibitor
A specific inhibitor of thromboxane A2 (TxA2) synthesis, CGS-13080, was studied during acute myocardial ischemia (MI) in cats. To… 
1983
1983
Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models.
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