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Endothelium-derived microparticles impair endothelial function in vitro.
Endothelial cell dysfunction (ECD) is emerging as the common denominator for diverse and highly prevalent cardiovascular diseases. Recently, an increased number of procoagulant circulatingExpand
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Carbon monoxide and cerebral microvascular tone in newborn pigs.
The present study addresses the hypothesis that CO produced from endogenous heme oxygenase (HO) can dilate newborn cerebral arterioles. HO-2 protein was highly expressed in large and small bloodExpand
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Heme oxygenase substrates acutely lower blood pressure in hypertensive rats.
Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substratesExpand
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Endothelial Dysfunction and Hypertension in Rats Transduced With CYP4A2 Adenovirus
Vascular cytochrome P450 (CYP) 4A enzymes catalyze the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid which participates in the regulation of vascular tone by sensitizing theExpand
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Nitric oxide synthesis influences the renal vascular response to heme oxygenase inhibition.
We studied the effects of the heme oxygenase (HO) inhibitor stannous mesoporphyrin (SnMP; 40 micromol/kg i.v.) on renal hemodynamics in anesthetized rats with and without 48-h pretreatment withExpand
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Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation.
Our goal was to determine whether angiotensin II (Ang II) and its metabolic fragments release nitric oxide and the mechanisms by which this occurs in blood vessels from the canine heart. We incubatedExpand
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A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats.
Heme oxygenase is a mammalian enzyme that converts heme to biliverdin and carbon monoxide. Carbon monoxide activates soluble guanylate cyclase and relaxes vascular smooth muscle, and it has beenExpand
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Prevention and Reversal of Premature Endothelial Cell Senescence and Vasculopathy in Obesity-Induced Diabetes by Ebselen
Abstract— Although the accelerated atherosclerosis and premature aging of the cardiovascular system in patients with metabolic syndrome have been appreciated, the mechanisms of their development andExpand
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Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors.
Rat renal interlobar arteries express heme oxygenase 2 (HO-2) and manufacture carbon monoxide (CO), which is released into the headspace gas. CO release falls to 30% and 54% of control, respectively,Expand
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Role of nitric oxide in the control of renal oxygen consumption and the regulation of chemical work in the kidney.
Inhibition of NO synthesis has recently been shown to increase oxygen extraction in vivo, and NO has been proposed to play a significant role in the regulation of oxygen consumption by both skeletalExpand
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