CER-001
National Institutes of Health
Papers overview
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Importance CER-001 is a negatively charged, engineered pre-&bgr; high-density lipoprotein (HDL) mimetic containing apolipoprotein…
BACKGROUND
CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol…
BACKGROUND
High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy…
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease…
Objective CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was…
Aim High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies…
Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder, associated with elevated levels of low-density…
Background: CER-001 is a synthetic HDL, comprised of recombinant human ApoA-I complexed with phospholipids and designed to mimic…