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CER-001

National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Apolipoprotein A-IPhospholipidsRecombinant Proteins

Papers overview

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Highly Cited
2018
Highly Cited
2018
Effect of Serial Infusions of CER-001, a Pre-&bgr; High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis…
Importance CER-001 is a negatively charged, engineered pre-&bgr; high-density lipoprotein (HDL) mimetic containing apolipoprotein… 
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2017
2017
Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.
BACKGROUND High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy… 
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2017
2017
Regression of coronary atherosclerosis with infusions of the high-density lipoprotein mimetic CER-001 in patients with more extensive plaque burden.
BACKGROUND CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol… 
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2016
2016
HDL mimetic CER-001 targets atherosclerotic plaques in patients.
BACKGROUND AND AIMS Infusion of high-density lipoprotein (HDL) mimetics aimed at reducing atherosclerotic burden has led to… 
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Highly Cited
2015
Highly Cited
2015
Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA[S]
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease… 
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Highly Cited
2015
Highly Cited
2015
The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The…
BACKGROUND Patients with homozygous familial hypercholesterolemia (HoFH) are at extremely elevated risk for early cardiovascular… 
2015
2015
HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation
Objective CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was… 
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Highly Cited
2014
Highly Cited
2014
Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial†
Aim High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies… 
Highly Cited
2014
Highly Cited
2014
CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice.
OBJECTIVE CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and phospholipids that was designed to… 
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Review
2013
Review
2013
Diagnosis and treatment of familial hypercholesterolaemia.
Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder, associated with elevated levels of low-density… 
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