Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men
- J. Stone, S. Holland, S. Waldman
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 March 2002
The pharmacokinetics of caspofungin supports the clinical evaluation of once-daily dosing regimens for efficacy against fungal infections.
Multiple‐Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
- J. Kovarik, R. Schmouder, Denise Barilla, G. Rivière, Yibin Wang, T. Hunt
- Medicine, BiologyJournal of clinical pharmacology
- 1 May 2004
Systemic exposure to FTY720 was consistent with dose‐proportionality after both single‐ and multiple‐dose administration, and exposure‐response modeling provided evidence that 5 mg/day FTY 720 resulted in a near‐maximal dynamic effect of this drug on lymphocytes.
Pharmacokinetics and Steady-State Bioequivalence of Treprostinil Sodium (Remodulin®) Administered by the Intravenous and Subcutaneous Route to Normal Volunteers
- K. Laliberte, C. Arneson, R. Jeffs, T. Hunt, M. Wade
- MedicineJournal of Cardiovascular Pharmacology
- 1 August 2004
It was concluded that intravenously and subcutaneously administered treprostinil are bioequivalent at steady state.
Single‐ and Multiple‐Dose Pharmacokinetics of Etoricoxib, a Selective Inhibitor of Cyclooxygenase‐2, in Man
- N. Agrawal, A. Porras, K. Gottesdiener
- MedicineJournal of clinical pharmacology
- 1 March 2003
Steady‐state pharmacokinetics of etoricoxib, achieved following 7 days of once‐daily dosing, were found to be reasonably predicted from single doses, and the drug was generally well tolerated.
Pregabalin pharmacokinetics and safety in healthy volunteers Results from two phase 1 studies
- H. Bockbrader, T. Hunt, J. Strand, E. Posvar, A. Sedman
- Biology
- 16 February 2000
Absolute Bioavailability and Pharmacokinetics of Treprostinil Sodium Administered by Acute Subcutaneous Infusion
- M. Wade, F. Baker, R. Roscigno, W. DellaMaestra, T. Hunt, A. Lai
- MedicineJournal of clinical pharmacology
- 1 January 2004
It was concluded that treprostinil administered by subcutaneous administration is completely absorbed, with a slightly longer half‐life compared to intravenously administered treproStinil.
The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects.
- J. Kovarik, A. Slade, R. Schmouder
- Medicine, BiologyBritish Journal of Clinical Pharmacology
- 1 August 2008
Atropine administered concurrently with fingolimod prevented the heart rate nadir that typically occurs 4 h postdose and was able to reverse the negative chronotropic effect of fingolIMod.
Absence of pharmacokinetic interaction between orally co‐administered naproxen sodium and diphenhydramine hydrochloride
- R. D. Toothaker, S. Barker, J. Powell
- Chemistry, BiologyBiopharmaceutics & drug disposition
- 1 September 2000
Based on absence of significant treatment effects on AUC and Cmax, single‐dose oral co‐administration of 220 mg of naproxen sodium with 50 mg of diphenhydramine hydrochloride does not alter the pharmacokinetics of either naproxin or diphenHydramine.
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