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Single- and Multiple-Dose Pharmacokinetics of Caspofungin in Healthy Men
The pharmacokinetics of caspofungin supports the clinical evaluation of once-daily dosing regimens for efficacy against fungal infections. Expand
Multiple‐Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
Systemic exposure to FTY720 was consistent with dose‐proportionality after both single‐ and multiple‐dose administration, and exposure‐response modeling provided evidence that 5 mg/day FTY 720 resulted in a near‐maximal dynamic effect of this drug on lymphocytes. Expand
Pharmacokinetics and Steady-State Bioequivalence of Treprostinil Sodium (Remodulin®) Administered by the Intravenous and Subcutaneous Route to Normal Volunteers
It was concluded that intravenously and subcutaneously administered treprostinil are bioequivalent at steady state. Expand
Single‐ and Multiple‐Dose Pharmacokinetics of Etoricoxib, a Selective Inhibitor of Cyclooxygenase‐2, in Man
Steady‐state pharmacokinetics of etoricoxib, achieved following 7 days of once‐daily dosing, were found to be reasonably predicted from single doses, and the drug was generally well tolerated. Expand
Safety, Tolerability, and Pharmacokinetic Properties of Intravenous Delafloxacin After Single and Multiple Doses in Healthy Volunteers.
Delafloxacin was well tolerated in healthy volunteers after single and multiple IV doses, supporting that a switch between the 2 formulations is appropriate. Expand
The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects.
Atropine administered concurrently with fingolimod prevented the heart rate nadir that typically occurs 4 h postdose and was able to reverse the negative chronotropic effect of fingolIMod. Expand
Effects of three fluoroquinolones on QT interval in healthy adults after single doses
A clinical trial was conducted in healthy adult volunteers to assess the effect of levofloxacin, moxifloxacin, and ciprofloxacin on the QT and QTc interval.
The effect of rofecoxib on the pharmacodynamics and pharmacokinetics of warfarin
The objective of this study was to examine the effect of 3 doses of rofecoxib on the pharmacodynamics and pharmacokinetics of warfarin. Expand
Absolute Bioavailability and Pharmacokinetics of Treprostinil Sodium Administered by Acute Subcutaneous Infusion
It was concluded that treprostinil administered by subcutaneous administration is completely absorbed, with a slightly longer half‐life compared to intravenously administered treproStinil. Expand