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CDKN1B gene

Known as: CYCLIN-DEPENDENT KINASE INHIBITOR 1B, Cyclin Dependent Kinase Inhibitor 1B Gene, P27KIP1 
This gene is involved in cell cycle regulation and cyclin regulation.
National Institutes of Health

Related topics

Related topics

4 relations
Beckwith-Wiedemann SyndromeCell Cycle Controlcyclin-dependent kinase inhibitor 1B

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CDKN1B wt Allele

Papers overview

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2016
2016
p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress
The DNA damage response (DDR) is a coordinated signaling network that ensures the maintenance of genome stability under DNA… 
Highly Cited
2007
Highly Cited
2007
RETRACTION: Erlotinib, an Effective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces p27KIP1 Up-Regulation and Nuclear Translocation in Association with Cell Growth Inhibition and…
Erlotinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been shown to have potent… 
Review
2007
Review
2007
Duality of p27Kip1 function in tumorigenesis.
In this issue of Genes & Development, Besson et al. (2007) report phenotypic characteristics of a novel knock-in mouse strain… 
Highly Cited
2006
Highly Cited
2006
Cyclin D1 induction of cellular migration requires p27(KIP1).
The cyclin D1 gene is amplified and overexpressed in human breast cancer, functioning as a collaborative oncogene. As the… 
2003
2003
The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest.
HR12 is a novel farnesyltransferase inhibitor (FTI). We have shown previously that HR12 induces phenotypic reversion of H-rasV12… 
Highly Cited
2003
Highly Cited
2003
Skp2 and Jab1 Expression Are Associated with Inverse Expression of p27KIP1 and Poor Prognosis in Oral Squamous Cell Carcinomas
Previous studies have shown that low levels of p27KIP1, an inhibitor of G1 cyclin-dependent kinases (CDK), are associated with… 
Highly Cited
1999
Highly Cited
1999
Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells
Recent studies have shown that decreased expression of p27Kip1 is associated with high grade tumors and an unfavorable prognosis… 
Highly Cited
1999
Highly Cited
1999
E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I.
The heart is a postmitotic organ unable to regenerate after injury. The mechanisms controlling cell cycle arrest in… 
Highly Cited
1996
Highly Cited
1996
Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.
We have shown previously that loss of heterozygosity at chromosome band 12p13 is among the most frequent genetic abnormalities… 
Highly Cited
1996
Highly Cited
1996
Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.
Cytogenetic analysis of acute lymphoblastic leukemia (ALL) of childhood identified nonrandom chromosomal abnormalities of the… 
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