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The DNA damage response (DDR) is a coordinated signaling network that ensures the maintenance of genome stability under DNA… Expand Pheochromocytomas are neoplasias of neural crest origin that arise from the chromaffin cells of the adrenal medulla… Expand The one or more underlying mechanisms of the tumor suppressing activity of the histidine triad nucleotide-binding protein 1… Expand Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors… Expand The mammalian cyclin-dependent kinase inhibitor (CDKI) p27 is a potent regulator of cell cycle arresting transition from G1 to S… Expand HR12 is a novel farnesyltransferase inhibitor (FTI). We have shown previously that HR12 induces phenotypic reversion of H-rasV12… Expand The cyclin-dependent kinase (CDK) inhibitors p27 Kip1 and p57 Kip2 are thought to regulate progression of the cell cycle. We have… Expand ABSTRACT Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor regulate the survival, proliferation… Expand Recent studies have shown that decreased expression of p27Kip1 is associated with high grade tumors and an unfavorable prognosis… Expand Cyclin-dependent kinase (CDK) inhibitor genes encode low molecular weight proteins which have important functions in cell cycle… Expand