FAQ

CDK6-associated protein p18

Known as: Cyclin-Dependent Inhibitor, Cyclin Dependent Kinase Inhibitor p18, p18INK4c Protein 
An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN-LIKE REPEATS. Aberrant expression of this protein has been associated with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2016
051019962016

Related topics

Related topics

25 relations
Ankyrin RepeatCDKN2C geneCell Cycle ControlCell Nucleus
(More)

Broader (1)

Protein Kinase Inhibitors

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CDK6-associated protein p18
Cell Nucleus
physiological aspects
agonists
Pancreas
Skeletal muscle structure

Papers overview

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2015
2015
Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing.
Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often unresponsive to available therapeutic… (More)
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Highly Cited
2010
Highly Cited
2010
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value.
To obtain a comprehensive genomic profile of presenting multiple myeloma cases we performed high-resolution single nucleotide… (More)
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2009
2009
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
Mammary epithelia are composed of luminal and myoepithelial/basal cells whose neoplastic transformations lead to distinct types… (More)
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Highly Cited
2009
Highly Cited
2009
Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.
Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary… (More)
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2007
2007
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
High-risk susceptibility genes explain <40% of the excess risk of familial ovarian cancer. Therefore, other ovarian cancer… (More)
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Highly Cited
2007
Highly Cited
2007
Primitive hematopoietic cells resist HIV-1 infection via p21.
Hematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase… (More)
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Highly Cited
2005
Highly Cited
2005
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Recurrent genetic alterations in human medulloblastoma (MB) include mutations in the sonic hedgehog (SHH) signaling pathway and… (More)
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Highly Cited
2004
Highly Cited
2004
Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs.
To characterize the molecular feature in prostate carcinogenesis and the putative transition from prostatic intraepithelial… (More)
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2002
2002
Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis
Multiple myeloma (MM) is a clonal neoplasm of plasma cells which offers an excellent model to study multistep molecular… (More)
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Highly Cited
2001
Highly Cited
2001
Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas.
We investigated 67 meningothelial tumors (20 benign meningiomas, 34 atypical meningiomas, and 13 anaplastic meningiomas) for… (More)
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