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CDK6-associated protein p18

Known as: Cyclin-Dependent Inhibitor, Cyclin Dependent Kinase Inhibitor p18, p18INK4c Protein 
An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN-LIKE REPEATS. Aberrant expression of this protein has been associated with… 
National Institutes of Health

Related topics

Related topics

23 relations
Ankyrin RepeatCDKN2C geneCell Cycle ControlCell Nucleus

Broader (1)

Protein Kinase Inhibitors

Papers overview

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Highly Cited
2007
Highly Cited
2007
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
P276-00, a flavone that inhibits cyclin-dependent kinases, has been identified by us recently as a novel antineoplastic agent. In… 
Highly Cited
2006
Highly Cited
2006
The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down…
Mechanisms of lethality of the three-substituted indolinone and putatively selective cyclin-dependent kinase (CDK)2 inhibitor 3… 
Highly Cited
2004
Highly Cited
2004
Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker
Transient myeloproliferative disorder (TMD) is a unique, spontaneously regressing neoplasia specific to Down's syndrome (DS… 
Highly Cited
2004
Highly Cited
2004
Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Inhibition of cyclin A- and cyclin E-associated cyclin-dependent kinase-2 (CDK2) activities is an effective way of selective… 
Highly Cited
2002
Highly Cited
2002
DNA Damage Invokes Mismatch Repair-dependent Cyclin D1 Attenuation and Retinoblastoma Signaling Pathways to Inhibit CDK2*
DNA-damage evokes cell cycle checkpoints, which function to maintain genomic integrity. The retinoblastoma tumor suppressor (RB… 
Highly Cited
2000
Highly Cited
2000
Activating Transcription Factor 2 Is Necessary for Maximal Activity and Serum Induction of the Cyclin A Promoter in Chondrocytes*
Endochondral bone growth is regulated through the proliferation and differentiation of growth plate chondrocytes. Mice deficient… 
Highly Cited
2000
Highly Cited
2000
Inhibition of Mitogenesis in Balb/c-3T3 Cells by Trichostatin A
Trichostatin A (TSA), a global repressor of histone deacetylase activity, inhibits the proliferation of a number of cell types… 
Highly Cited
1998
Highly Cited
1998
A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes
In different systems, cyclic adenosine monophosphate (cAMP) either blocks or promotes cell cycle progression in mid to late G1… 
Highly Cited
1997
Highly Cited
1997
Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes
P130 shares structural and functional homology with pRb and p107. One property common to p107 and p130, but not to pRb, is the… 
Highly Cited
1986
Highly Cited
1986
The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes
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