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CDK6-associated protein p18

Known as: Cyclin-Dependent Inhibitor, Cyclin Dependent Kinase Inhibitor p18, p18INK4c Protein 
An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN-LIKE REPEATS. Aberrant expression of this protein has been associated with… 
National Institutes of Health

Related topics

Related topics

23 relations
Ankyrin RepeatCDKN2C geneCell Cycle ControlCell Nucleus

Broader (1)

Protein Kinase Inhibitors

Papers overview

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Review
2006
Review
2006
Different Mechanisms of CDK 5 and CDK 2 Activation as Revealed by CDK 5 / p 25 and CDK 2 / Cyclin A Dynamics
A detailed analysis is presented of the dynamics of human CDK5 in complexes with the protein activator p25 and the purine-like… 
2005
2005
Transcriptional Regulation of Cyclin A 2 by RASSF 1 A through the Enhanced Binding of p 120 E 4 F to the Cyclin A 2 Promoter
Recent advances in the study of RASSF1A , the candidate tumor suppressor gene, indicate a possible role of RASSF1A in cell cycle… 
2005
2005
Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity
2003
2003
The Cyclin D 1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB MCM 7 Binding *
The capacity of the cyclin D-dependent kinase to promote G1 progression through modulation of RB E2F is well documented. We now… 
2003
2003
Loss of p 16 Contributes to p 27 Sequestration by Cyclin D 1-Cyclin-dependent Kinase 4 Complexes and Poor Prognosis in Hepatocellular Carcinoma
Purpose: p27 (p27) might act as an adverse prognostic marker for various types of cancers. However, its clinical usefulness… 
2001
2001
Cleavage of cyclin A at R 70 y R 71 by the bacterial protease OmpT
Previous work has shown that cyclin A can be cleaved at Arg-70y Arg-71 by a proteolytic activity present in an in vitro-coupled… 
2000
2000
Levels of Cyclin D 1 and D 3 in Malignant Melanoma : Deregulated Cyclin D 3 Expression Is Associated with Poor Clinical Outcome in Superficial Melanoma 1
We examined 172 primary (110 superficial and 62 nodular) and 73 metastatic melanomas, as well as 10 benign nevi, for protein… 
1999
1999
Anchorage-dependent expression of cyclin A in primary cells requires a negative DNA regulatory element and a functional Rb
Many cells, when cultured in suspension, fail to express cyclin A, a regulatory component of cell cycle kinases cdc2 and cdk2 and… 
1999
1999
E 2 F-1 Has Properties of a Radiosensitizer and Its Regulation by Cyclin A Kinase Is Required for Cell Survival of Fibrosarcoma Cells Lacking p 531
Negative regulation of E2F-1 DNA binding function by cyclin A kinase represents part of an S-phase checkpoint control system that… 
1996
1996
Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1.
OBJECTIVE The p21Cip1 protein is a potent stoichiometric inhibitor of cyclin-dependent kinase activity, and p21Cip1 mRNA…