A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes

@article{Depoortere1998ARF,
  title={A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes },
  author={Fabienne Depoortere and Alexandra Van Keymeulen and Jiri Lukas and Sabine Costagliola and Jirina Bartkova and Jacques E. Dumont and Jiri Bartek and Pierre P Roger and Sarah Dremier},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={1427 - 1439}
}
In different systems, cyclic adenosine monophosphate (cAMP) either blocks or promotes cell cycle progression in mid to late G1 phase. Dog thyroid epithelial cells in primary culture constitute a model of positive control of DNA synthesis initiation and G0-S prereplicative phase progression by cAMP as a second messenger for thyrotropin (TSH). The cAMP-dependent mitogenic pathway is unique as it is independent of mitogen-activated protein kinase activation and differs from growth factor-dependent… CONTINUE READING

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