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CDH1 protein, human

Known as: CD324 Antigen, cadherin 1, type 1, E-cadherin (epithelial) protein, human, Cadherin 1 
Cadherin-1 (882 aa, ~97 kDa) is encoded by the human CHD1 gene. This protein plays a role in the regulation of cell-cell adhesion, proliferation, and… 
National Institutes of Health

Related topics

Related topics

25 relations
Breast CarcinomaCDH1 geneCDH1 wt AlleleCadherin Domain

Broader (2)

CadherinsE-Cadherin

Papers overview

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Highly Cited
2010
Highly Cited
2010
Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer
Background Lung cancer is the leading cause of cancer deaths worldwide. New diagnostics are needed to detect early stage lung… 
Highly Cited
2008
Highly Cited
2008
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.
The correct targeting and trafficking of the adherens junction protein epithelial cadherin (E-cadherin) is a major determinant… 
Highly Cited
2006
Highly Cited
2006
Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions.
Compared with type I cytokine-associated myeloid (M1) cells, the molecular repertoire and mechanisms underlying functional… 
Highly Cited
2003
Highly Cited
2003
Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila
Cell rearrangement, accompanied by the rapid assembly and disassembly of cadherin-mediated cell adhesions, plays essential roles… 
Highly Cited
2001
Highly Cited
2001
Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E… 
Highly Cited
1997
Highly Cited
1997
E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms.
Expression of the calcium-dependent adhesion molecule E-cadherin suppresses the invasion of cells in vitro, but the mechanism of… 
Highly Cited
1996
Highly Cited
1996
Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression (*)
Epithelium-specific gene expression is fundamental in both embryogenesis and the maintenance of adult tissues, and impairment of… 
Highly Cited
1991
Highly Cited
1991
Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities.
Loss of cell-cell adhesion in carcinoma cells may be an important step in the acquisition of an invasive, metastatic phenotype… 
Highly Cited
1990
Highly Cited
1990
Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin
All Ca2(+)-dependent cell adhesion molecules are synthesized as precursor polypeptides followed by a series of posttranslational… 
Highly Cited
1989
Highly Cited
1989
Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors.
Polyclonal and monoclonal antibodies raised to the 80 kd glycoprotein component of the cell to cell adhesion molecule cell-CAM… 
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