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Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics.
TLDR
It is concluded that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E- cadherIn for junction formation in development, tissue remodeling, and tumorigenesis.
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.
TLDR
A novel pathway for Rab11 dependent, dileucine-mediated, mu1B-independent sorting and basolateral trafficking, exemplified by E-cadherin is demonstrated, with a potentially important role in establishing and maintaining cadherin-based adhesion.
A Role for the Phagosome in Cytokine Secretion
TLDR
A joint trafficking pathway linking both actions of proinflammatory cytokine secretion and phagocytosis of pathogens is found, which may economize membrane transport and augment the immune response.
The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans1
TLDR
Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans.
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.
TLDR
During the development of epithelial cysts, DN-Rab11 disrupted E-cadherin targeting and trafficking, the subapical localization of pERM and actin, and cyst lumen formation, demonstrating an early and critical interdependence of Rab11 and the RE for E- cadher in targeting, apical membrane formation, and cell polarity in cysts.
The ins and outs of E-cadherin trafficking.
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin
TLDR
A role for SNX1 is demonstrated in retrieval of E-cadherin from a degradative endosomal pathway and in membrane trafficking pathways that regulate E- cadher in recycling in epithelia.
Cytokine release from innate immune cells: association with diverse membrane trafficking pathways.
TLDR
Research findings and new approaches that have begun to generate information on cytokine trafficking and release by innate immune cells in response to inflammatory or infectious stimuli are reviewed.
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