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CD70 gene

Known as: CD70 ANTIGEN, CD70 Molecule Gene, CD27L 
This gene is involved in immune function.
National Institutes of Health

Related topics

Related topics

9 relations
CD70 AntigenCell DeathCell Proliferation Regulatory ProcessCytokine Receptor Binding

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CD70 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.
Highly Cited
2009
Highly Cited
2009
Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor…
For many ligands of the TNF family, trimer stability and oligomerization status are crucial determinants of receptor activation… 
Highly Cited
2008
Highly Cited
2008
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity.
Highly Cited
2005
Highly Cited
2005
Demethylation of the Same Promoter Sequence Increases CD70 Expression in Lupus T Cells and T Cells Treated with Lupus-Inducing Drugs1
Exposing genetically predisposed individuals to certain environmental agents is believed to cause human lupus. How environmental… 
Highly Cited
2004
Highly Cited
2004
Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors.
OBJECTIVE Generalized DNA hypomethylation contributes to altered T cell function and gene expression in systemic lupus… 
Highly Cited
2004
Highly Cited
2004
Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation
In vivo priming of antigen-specific CD8+ T cells results in their expansion and differentiation into effector T cells followed by… 
Highly Cited
2003
Highly Cited
2003
Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo4
The interaction between TNFR family member CD27 and its ligand CD70 promotes lymphocyte expansion and effector cell formation. In… 
Highly Cited
2003
Highly Cited
2003
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions
Nat. Immunol. 4, 49–54 (2003). Panel labels in the legend to Figure 2 were incorrect. The corrected legend is printed below… 
Highly Cited
1999
Highly Cited
1999
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.
OX40 and its ligand (OX40L) have been implicated in T cell-dependent humoral immune responses. To further characterize the role… 
Highly Cited
1994
Highly Cited
1994
CD70 represents the human ligand for CD27.
The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor… 
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