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CD4+ CD25+ Regulatory T Cells

Known as: T-regulatory cell, regulatory T cell, T reg 
Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define… Expand
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Highly Cited
2007
Highly Cited
2007
Foxp3+ regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory… Expand
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Highly Cited
2006
Highly Cited
2006
Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4… Expand
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Review
2005
Review
2005
Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of… Expand
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Highly Cited
2005
Highly Cited
2005
Transforming growth factor (TGF)-β1 is a major pluripotential cytokine with a pronounced immunosuppressive effect and its… Expand
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Highly Cited
2005
Highly Cited
2005
Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract T cell–mediated immune responses. An… Expand
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Highly Cited
2005
Highly Cited
2005
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our… Expand
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Highly Cited
2005
Highly Cited
2005
CD4+CD25+ regulatory T (T reg) cells play a pivotal role in control of the immune response. Transforming growth factor-β (TGF… Expand
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Highly Cited
2005
Highly Cited
2005
T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) can evoke effective… Expand
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Highly Cited
2005
Highly Cited
2005
Naturally occurring CD4+CD25+ regulatory T cells (T reg) are pivotal in suppressing immune responses and maintaining tolerance… Expand
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