K. Hayakawa

Publications139
h-index52
Citations14,441
Highly Influential Citations408
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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1… Expand
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B cell development pathways.
B cell development is a highly regulated process whereby functional peripheral subsets are produced from hematopoietic stem cells, in the fetal liver before birth and in the bone marrow afterward.… Expand
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The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
The expression of B lineage associated genes during early B cell differentiation stages is not firmly established. Using cell surface markers and multiparameter flow cytometry, bone marrow (BM) cells… Expand
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Positive selection of natural autoreactive B cells.
Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are… Expand
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Identification of the earliest B lineage stage in mouse bone marrow.
We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow delineated by expression of AA4.1, a molecule found on stem cells and… Expand
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The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice
A small subpopulation of normal murine splenic B cells carrying all of the classic B cells markers (IgM, IgD, Ia, and ThB) also carries Ly-1, one of the major T cell surface molecules. This "Ly-1 B"… Expand
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Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14 + NK T Lymphocytes
Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses,… Expand
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Progenitors for Ly-1 B cells are distinct from progenitors for other B cells
Data from previous multiparameter fluorescence-activated cell sorter (FACS) analysis and sorting studies define a subset of murine B cells that expresses the Ly-1 surface determinant in conjunction… Expand
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A developmental switch in B lymphopoiesis.
  • R. Hardy, K. Hayakawa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 December 1991
B and T lymphocytes are generated from hematopoietic stem cells during both fetal and adult life. A critical unresolved issue is whether the differentiation pathways in lymphopoiesis are the same in… Expand
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CD5 B cells, a fetal B cell lineage.
Publisher Summary This chapter presents a short background of CD5 expression on B cells and focuses on the issue of the relationship of CD5 B cells to B cell development, proposing a model that views… Expand
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