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CD244 wt Allele

Known as: NAIL, 2B4, CD244 Molecule, Natural Killer Cell Receptor 2B4 wt Allele 
Human CD244 wild-type allele is located in the vicinity of 1q23.1 and is approximately 32 kb in length. This allele, which encodes natural killer… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

CD244 gene
Immune Cell Activation ProcessLigand BindingReceptor SignalingSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
SHIP Influences Signals from CD48 and MHC Class I Ligands That Regulate NK Cell Homeostasis, Effector Function, and Repertoire Formation
Previously, we showed that 2B4 is a dominant inhibitory receptor in SHIP-deficient NK cells that prevents efficient cytolysis of… 
2010
2010
The Association of MHC Class I Proteins with the 2B4 Receptor Inhibits Self-Killing of Human NK Cells
The killing activity of NK cells is carried out by several activating NK receptors, which includes NKp46, NKp44, NKp30, NKp80… 
2007
2007
Human natural killer cell receptor 2B4 (CD244) down-regulates its own expression by reduced promoter activity at an Ets element.
Review
2006
Review
2006
Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells.
2005
2005
An Ets element regulates the transcription of the human 2B4 gene in natural killer cells.
Highly Cited
2002
Highly Cited
2002
Association of the X-linked Lymphoproliferative Disease Gene Product SAP/SH2D1A with 2B4, a Natural Killer Cell-activating Molecule, Is Dependent on Phosphoinositide 3-Kinase*
Natural killer (NK) cells express an activating receptor, 2B4, that enhances cellular cytotoxicity. Upon NK cell activation by… 
Highly Cited
2002
Highly Cited
2002
2B4 Is Constitutively Associated with Linker for the Activation of T Cells in Glycolipid-Enriched Microdomains: Properties Required for 2B4 Lytic Function1
2B4 is a receptor belonging to the Ig superfamily and is found on all murine NK cells as well as a small subset of T cells… 
2001
2001
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.
The membrane receptor 2B4 is a CD2 family member that is involved in lymphocyte activation. A fraction of human CD8+ alphabeta T… 
2000
2000
Regulation of IFN-gamma production following 2B4 activation in human NK cells.
IFN-gamma is a cytokine that regulates various functions of the immune system. The major producers of IFN-gamma are T cells and… 
1999
1999
Molecular cloning and characterization of the promoter region of murine natural killer cell receptor 2B4.
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