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CCNE1 protein, human

Known as: Cyclin E, Cyclin-E1, CCNE1 
G1/S-specific cyclin-E1 (401 aa, ~47 kDa) is encoded by the human CCNE1 gene. This protein is involved in the progression of the cell cycle between… 
National Institutes of Health

Related topics

Related topics

15 relations
CCNE1 geneCell CycleCell Cycle ControlCell Nucleus

Broader (2)

Cyclin EOncogene Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer
Ovarian cancer is the most-deadly gynecologic malignancy, with greater than 14,000 women expected to succumb to the disease this… 
Highly Cited
2016
Highly Cited
2016
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition
Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous… 
Highly Cited
2016
Highly Cited
2016
Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer…
Purpose The mechanism of resistance to cisplatin during treatment of bladder cancer (BC) has been a subject of intense… 
Highly Cited
2016
Highly Cited
2016
CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma
Aberration in chromosomal structure characterizes almost all cancers and has profound biological significance in tumor… 
Highly Cited
2015
Highly Cited
2015
Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer
Background:Analysis of a microRNA (miRNA) expression signature of bladder cancer (BC) by deep-sequencing revealed that clustered… 
2015
2015
MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cells.
MicroRNAs are involved in diverse biological processes through regulation of gene expression. The microRNA profile has been shown… 
Highly Cited
2013
Highly Cited
2013
MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer.
MicroRNAs (miRNAs) are a small class of non-coding RNAs that are widely dysregulated in various cancers. They act as either… 
Highly Cited
2012
Highly Cited
2012
CBX7 is a tumor suppressor in mice and humans.
The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the… 
Highly Cited
2009
Highly Cited
2009
Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin.
BACKGROUND & AIMS E-cyclins control the transition of quiescent cells into the cell cycle. Two E-cyclins, CcnE1 and CcnE2, have… 
Highly Cited
2006
Highly Cited
2006
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene
The Cyclin E1 gene (CCNE1) is an ideal model to explore the mechanisms that control the transcription of cell cycle-regulated… 
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