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Small dsRNAs induce transcriptional activation in human cells
TLDR
A more diverse role for small RNA molecules in the regulation of gene expression than previously recognized is revealed and a potential therapeutic use for dsRNA in targeted gene activation is identified.
Identification of novel microRNA targets based on microRNA signatures in bladder cancer
TLDR
The target search algorithm and gene‐expression profiling in BCs revealed that Keratin7 (KRT7) mRNA was a common target of the downregulated miRNAs, and the mRNA expression levels of KRT7 were significantly higher inBCs than in NBEs.
miR‐145, miR‐133a and miR‐133b: Tumor‐suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma
TLDR
The identification of tumor‐suppressive miRNAs,miR‐145, miR‐133a and miR-133b, directly control oncogenic FSCN1 gene, and could provide new insights into potential mechanisms of ESCC carcinogenesis.
Epigenetic Inactivation of Wnt Inhibitory Factor-1 Plays an Important Role in Bladder Cancer through Aberrant Canonical Wnt/β-Catenin Signaling Pathway
TLDR
This is the first report showing that CpG hypermethylation of the Wif-1 promoter is a frequent event in bladder tumor and may contribute to pathogenesis of bladder cancer through aberrant canonical Wnt/β-catenin signaling pathway.
miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
TLDR
Tumour suppressivemiR-145 and miR-133a directly control oncogenic FSCN1 in BC, and both microRNAs repressed the mRNA and protein expression of F SCN1.
The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer
TLDR
The downregulation ofmiR-1 and miR-133a was a frequent event in BC, and these miRNAs were recognised as tumour suppressive and TAGLN2 may be a target of both mi RNAs and had a potential oncogenic function.
MiR‐96 and miR‐183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology
TLDR
MiR‐96 and miR‐183 in urine are promising tumor markers for UC and may be a good diagnostic marker in combination with urinary cytology.
Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC)
TLDR
Restoration of miR-375 showed significant inhibition of cell proliferation and induction of cell apoptosis in SAS and FaDu cell lines, suggesting that mi R-375 functions as a tumor suppressor.
Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.
TLDR
This is the first report demonstrating that M score analysis of Wnt-antagonist genes could serve as an excellent epigenetic biomarker panel for bladder tumors.
Tumor‐suppressive microRNA‐1291 directly regulates glucose transporter 1 in renal cell carcinoma
TLDR
The identification of novel tumor‐suppressive miR‐1291‐mediated molecular pathways and targets has provided new insights into RCC oncogenesis and metastasis.
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