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DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form… Expand Key studies defining the DNA alkylation properties and selectivity of a new class of exceptionally potent, naturally occurring… Expand Bis-indolyl-(seco)-1,2,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e compounds are synthetic analogues of CC-1065 that are highly… Expand CC-1065 is a potent antitumor antibiotic that binds covalently to N3 of adenine in the minor groove of DNA. The CC-1065 molecule… Expand CC-1065 is a unique antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of this drug are thought… Expand Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs… Expand It was previously shown that the potent new DNA-binding antibiotic, CC-1065, prolonged life span, but was not curative, when… Expand CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces zelensis, interacts strongly with double… Expand ( Received for publication June 15, 1981)CC-1065 (NSC 298223) is a potent new antitumor antibiotic with a unique structure… Expand A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp.n. The antibiotic is biologically… Expand