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CC 1065

Known as: Benzo(1,2-b:4,3-b')dipyrrole-3(2H)-carboxamide, 7-((1,6-dihydro-4-hydroxy-5-methoxy-7-((4,5,8,8a-tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1,6-dihydro-4-hydroxy-5-methoxy-, CC-1065 
National Institutes of Health

Papers overview

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Review
2004
Review
2004
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form… Expand
Review
1995
Review
1995
  • D. Boger, D. Johnson
  • Proceedings of the National Academy of Sciences…
  • 1995
  • Corpus ID: 14760463
Key studies defining the DNA alkylation properties and selectivity of a new class of exceptionally potent, naturally occurring… Expand
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Highly Cited
1995
Highly Cited
1995
Bis-indolyl-(seco)-1,2,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e compounds are synthetic analogues of CC-1065 that are highly… Expand
Highly Cited
1988
Highly Cited
1988
CC-1065 is a potent antitumor antibiotic that binds covalently to N3 of adenine in the minor groove of DNA. The CC-1065 molecule… Expand
Highly Cited
1985
Highly Cited
1985
CC-1065 is a unique antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of this drug are thought… Expand
Highly Cited
1984
Highly Cited
1984
Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs… Expand
Highly Cited
1984
Highly Cited
1984
It was previously shown that the potent new DNA-binding antibiotic, CC-1065, prolonged life span, but was not curative, when… Expand
Highly Cited
1982
Highly Cited
1982
CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces zelensis, interacts strongly with double… Expand
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Highly Cited
1981
Highly Cited
1981
( Received for publication June 15, 1981)CC-1065 (NSC 298223) is a potent new antitumor antibiotic with a unique structure… Expand
Highly Cited
1978
Highly Cited
1978
A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp.n. The antibiotic is biologically… Expand
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