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CC 1065

Known as: Benzo(1,2-b:4,3-b')dipyrrole-3(2H)-carboxamide, 7-((1,6-dihydro-4-hydroxy-5-methoxy-7-((4,5,8,8a-tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1,6-dihydro-4-hydroxy-5-methoxy-, CC-1065 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antibiotics, AntineoplasticIndoles
NSC 298223

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies.
In recent years, a series of new and highly cytotoxic analogues of CC-1065 and the duocarmycins have been developed that can be… 
2001
2001
Highly Selective Glycosylated Prodrugs of Cytostatic CC‐1065 Analogues for Antibody‐Directed Enzyme Tumor Therapy
Novel prodrugs of the cytotoxic antibiotic CC‐1065 for an antibody‐directed enzyme prodrug therapy (ADEPT) were prepared that… 
1992
1992
Reversibility of the covalent reaction of CC-1065 and analogues with DNA.
Covalent DNA adducts of the antitumor antibiotic CC-1065 and its analogues undergo a retrohomologous Michael reaction in aqueous… 
1991
1991
In vitro and in vivo DNA bonding by the CC-1065 analogue U-73975.
CC-1065, a cyclopropylpyrroloindole (CPI), is a highly potent antitumor DNA-alkylating agent. We have devised a simple method to… 
1990
1990
An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA.
The binding of the antitumor drug CC-1065 has been studied with nuclear magnetic resonance (NMR) spectroscopy. This study… 
Highly Cited
1988
Highly Cited
1988
Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.
The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on… 
1988
1988
Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases.
The recognition and repair of the helix-stabilizing and relatively nondistortive CC-1065-(N3-adenine)-DNA adduct by UVRABC… 
Highly Cited
1985
Highly Cited
1985
Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.
CC-1065 is a unique antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of this drug are thought… 
1985
1985
Binding of CC‐1065 to poly‐ and oligonucleotides
The binding of the antitumor agent CC‐1065 to a variety of poly‐ and oligonucleotides was studied by electronic absorption, CD… 
Highly Cited
1981
Highly Cited
1981
The structure of CC-1065, a potent antitumor agent and its binding to DNA
The crystal and molecular structure of a potent antitumor agent, CC1065 (C37H33N708), has been determined, and circular dichroism… 
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