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O-demethylpaulomycins A and B, U-77,802 and U-77,803, paulomenols A and B, new metabolites produced by Streptomyces paulus.
TLDR
Five new metabolites related to paulomycins A and B have been isolated from fermentations of Streptomyces paulus strain 273 and the antibacterial properties are briefly discussed. Expand
CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity.
TLDR
CC-1065 (NSC 298223) is a potent new antitumor antibiotic with a unique structure produced by Streptomyces zelensis and improved production, isolation, and assay methods are described. Expand
New paulomycins produced by Streptomyces paulus.
TLDR
Five new paulomycins have been isolated from fermentations of Streptomyces paulus strain 273 and the structure of these compounds was determined using NMR and mass spectroscopic techniques. Expand
Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa.
TLDR
The gorgonian coral Pseudoplexaura porosa contains a lipoxygenase capable of converting exogenous arachidonic acid into (8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid, which was determined unambiguously by comparison of oxidative ozonolysis fragments with authentic malic acid-derived standards. Expand
Isolation and identification of a major metabolite of PNU-107859, an MMP inhibitor from the biliary fluid of rats.
PNU-107859, an important representative structure in a novel class of matrix metalloproteinases (MMP) inhibitors known as thiadiazoles, was found to be quickly eliminated from rats. A majorExpand
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