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Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
TLDR
In CDC25B, both sulfate and tungstate anions are shown to bind in the catalytic site containing the signature motif (HCxxxxxR) in a conformation similar to that of other protein tyrosine phosphatases and dual specificity phosphatase, with the exception of the Cdc25A. Expand
Absorption, excretion and half-life of clinimycin in normal adult males.
TLDR
It was found that food, including coffee and milk, had little, if any, effect on the antibacterial activities of serum and urine following oral administration of single doses of the antibiotic clinimycin. Expand
Pyrimidine and triazine 3-oxide sulfates: a new family of vasodilators.
TLDR
The structure of the O-sulfate of 2,4-diamino-6-piperidinylpyrimidine 3-oxide was confirmed by X-ray and apparently act by direct vasodilation. Expand
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.
TLDR
The conformationally restricted linear tricyclic analogs of 5- and 8-hydroxy-2-(di-n-propylamino)-tetralins were investigated for their serotonergic and dopaminergic properties and the presence of an additional methyl group at the C-2 position resulted in enhancement of in vitro 5-HT1A receptor binding affinity. Expand
INFLUENCE OF CHEMICAL AND PHYSICAL FACTORS ON BIOLOGICAL RESPONSES TO NEOMYCINS B AND C.
TLDR
The two known components of the neomycin complex—neomycins B and C—have been shown to respond differently under the usual conditions of bioassay, and a critical analysis of existing methods and standards is recommended. Expand
The structure of CC-1065, a potent antitumor agent and its binding to DNA
The crystal and molecular structure of a potent antitumor agent, CC1065 (C37H33N708), has been determined, and circular dichroism studies have demonstrated a strong interaction between CC-1065 andExpand
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