I. Gebhard

Publications17
h-index9
Citations396
Highly Influential Citations6
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Parasitism of Monarch Butterflies (Danaus Plexippus) by Lespesia Archippivora (Diptera: Tachinidae)
TLDR
Report of parasitism rates by this tachinid fly in wild captured monarchs, using data collected over 7 y by 77 volunteers in the Monarch Larva Monitoring Project, suggests that females either respond to larger hosts by laying more eggs or that superparasitism (parasitic by more than one individual) occurs.
Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065
TLDR
Adozelesin appears to be more effective than these drugs in the treatment of very resistant tumors such as s.p.- or s.c.-implanted mouse B16 melanoma, pancreatic 02 carcinoma, and human colon CX-1 and human lung LX-1 tumor xenografts.
Tachinid Fly (Diptera: Tachinidae) Parasitoids of Danaus plexippus (Lepidoptera: Nymphalidae)
TLDR
This work documents the tachinid community that attacks monarchs in the United States, evaluates their relative frequency, and examines variation in their specificity, oviposition strategy, and use of host stages.
Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.
TLDR
Structural-activity analysis supports a molecular mechanism for biological action involving hydrophobic interaction of the drug with DNA and acid-catalyzed alkylation of DNA.
Sequence Specificity of DNA Alkylation by the Unnatural Enantiomer of CC-1065 and Its Synthetic Analogues
Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogs
12,13-Isobaccatin III. Taxane Enol Esters (12,13-Isotaxanes)
Synthesis of (R)- and (S)-(glu)thz and the corresponding bisthiazole dipeptide of dolastatin 3
Synthese de (R)- et (S)-(glu)Thz (acides [amino-1' carboxy-3' propyl]-2 thiazolecarboxyliques-4) et du dipeptide (glu)Thz-(gly)Thz ((gly)Thz=acide aminomethyl-2 thiazolecarboxylique-4)
Taxol chemistry. 7-O-triflates as precursors to olefins and cyclopropanes
12,13-isotaxanes: synthesis of new potent analogs and X-ray crystallographic confirmation of structure.
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