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CBR1 protein, human

Known as: carbonyl reductase 1, human, Prostaglandin-E(2) 9-Reductase, 15-Hydroxyprostaglandin Dehydrogenase 
Carbonyl reductase [NADPH] 1 (277 aa, ~30 kDa) is encoded by the human CBR1 gene. This protein plays a role in the reduction of carbonyl compounds.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (2)

Alcohol Oxidoreductasescarbonyl reductase (NADPH)
Arachidonic Acid Metabolism PathwayCBR1 geneDrug Metabolism InductionEicosanoid Modulation

Papers overview

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Highly Cited
2017
Highly Cited
2017
Enzymatic synthesis of an ezetimibe intermediate using carbonyl reductase coupled with glucose dehydrogenase in an aqueous-organic solvent system.
Review
2007
Review
2007
Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.
Carbonyl groups are frequently found in endogenous or xenobiotic compounds. Reactive carbonyls, formed during lipid peroxidation… 
Highly Cited
2006
Highly Cited
2006
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Prostaglandin E(2) plays a growth-stimulatory role in breast cancer, and the rate-limiting enzyme in its synthesis… 
Review
2006
Review
2006
Multiplicity of mammalian reductases for xenobiotic carbonyl compounds.
A variety of carbonyl compounds are present in foods, environmental pollutants, and drugs. These xenobiotic carbonyl compounds… 
Review
2006
Review
2006
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions.
NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15(S)-hydroxyl group of prostaglandins… 
Highly Cited
1997
Highly Cited
1997
Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
Highly Cited
1995
Highly Cited
1995
Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae
A cytosolic aldo-keto reductase was purified from Saccharomyces cerevisiae ATCC 26602 to homogeneity by affinity chromatography… 
Highly Cited
1995
Highly Cited
1995
Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver.
Highly Cited
1992
Highly Cited
1992
Pig testicular 20 beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity. cDNA cloning of pig testicular 20 beta-hydroxysteroid dehydrogenase.
Highly Cited
1981
Highly Cited
1981
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
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